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Polyphenols of Myrica faya inhibit key enzymes linked to type II diabetes and obesity and formation of advanced glycation end-products (in vitro): Potential role in the prevention of diabetic complications
Food Research International ( IF 7.0 ) Pub Date : 2018-10-04 , DOI: 10.1016/j.foodres.2018.10.010
Vítor Spínola , Eulogio J. Llorent-Martínez , Paula C. Castilho

Myrica faya Aiton (fire tree, faya) is an underused species with a diverse flavonoid composition (anthocyanins, flavonols, ellagitannins) which can promote positive effects on human health. M. faya has been reported to possess high antioxidant activities, but its potential in the prevention of type II diabetes has not been evaluated so far. In the present study, eight M. faya samples from different areas of Madeira and Azores archipelagos (Portugal) were collected to determine their phytochemical profile and then tested for their in vitro anti-diabetic and antioxidant activities. The analyzed extracts showed strong inhibitory activities towards α -glucosidase, aldose reductase and glycation of bovine serum albumin (BSA) and moderate effects towards α-amylase and lipase (by comparison with reference compounds). Cyanidin-3-O-glucoside and ellagitannins were the main bioactive agents involved in the anti-diabetic effects of M. faya. Such results may provide important scientific evidence for further utilization of M. faya as dietary or nutraceutical products for the prevention and/or control of hyperglycaemia-associated complications.



中文翻译:

的多酚杨梅法雅禁止链接到II型糖尿病和肥胖形成的晚期糖化终产物(关键酶在体外):在预防糖尿病并发症的潜在作用

杨梅Faya Aiton(火树,faya)是一种未被充分利用的物种,具有多种类黄酮成分(花青素,黄酮醇,鞣花单宁),可促进对人类健康的积极影响。据报道,faya Maya具有很高的抗氧化活性,但到目前为止,其在预防II型糖尿病方面的潜力尚未得到评估。在本研究中,收集了来自马德拉群岛和亚速尔群岛群岛(葡萄牙)不同地区的八种法氏疟原虫样品,以确定其植物化学特征,然后进行了体外测试。抗糖尿病和抗氧化活性。分析的提取物显示出对牛血清白蛋白(BSA)的α-葡萄糖苷酶,醛糖还原酶和糖基化的强烈抑制活性,以及​​对α-淀粉酶和脂肪酶的中等抑制作用(与参考化合物比较)。Cyanidin-3- O-葡萄糖苷和鞣花单宁是参与faya faya的抗糖尿病作用的主要生物活性剂。这样的结果可能为进一步将法氏疟原虫作为饮食或营养产品用于预防和/或控制与高血糖相关的并发症提供重要的科学证据。

更新日期:2018-10-05
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