Dual-channel near-infrared fluorescent probe for real-time tracking of endogenous γ-glutamyl transpeptidase activity†,Chemical Communications

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Dual-channel near-infrared fluorescent probe for real-time tracking of endogenous γ-glutamyl transpeptidase activity†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-10-04 00:00:00 , DOI: 10.1039/c8cc07376g
Bing Bai _{1,

2,

3,

4,

5} , Chenxu Yan _{1,

2,

3,

4,

5} , Yutao Zhang _{1,

2,

3,

4,

5} , Zhiqian Guo _{1,

2,

3,

4,

5} , Wei-Hong Zhu _{1,

2,

3,

4,

5}

Affiliation

A curcuminoid difluoroboron-based tumor-targeting GGT-activatable fluorescent probe (Glu-DFB-biotin) is designed, which has remarkable characteristics of dual-channel and light-up near-infrared (NIR) fluorescence. Furthermore, Glu-DFB-biotin can differentiate hepatic cancer cells from normal cells and is successfully employed for real-time tracking of endogenous GGT activity in living cells.

中文翻译：

双通道近红外荧光探针可实时跟踪内源性γ-谷氨酰转肽酶活性†

设计了一种基于姜黄素的基于二氟硼的靶向肿瘤的GGT激活荧光探针（Glu-DFB-生物素），该探针具有双通道和近红外（NIR）荧光的显着特征。此外，Glu-DFB-生物素可将肝癌细胞与正常细胞区分开，并成功用于实时追踪活细胞中内源性GGT活性。

更新日期：2018-10-04

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