Filipendula vulgaris Moench (dropwort) is used in traditional medicine for relieving various inflammation-related diseases. In the present study, the phytochemical profile of F. vulgaris aerial part (FVA) and root (FVR) methanolic extracts was evaluated by LC-DAD-HRMS analysis. Furthermore, their in vitro and in vivo anti-inflammatory effects, as well as their potential cytotoxicity, were assessed. Results showed that the extracts mainly contain phenolics like flavonoids, hydrolyzable tannins, procyanidins, and phenolic acid derivatives, including gaultherin. No in vitro cytotoxicity was found at the highest concentration (50 μg/mL). FVA extract (50 μg/mL) significantly inhibited cyclooxygenase-1 and -2 (COX-1 and COX-2) activities in vitro (>50% inhibition), and FVR extract considerably inhibited COX-2 activity (52.5 ± 2.7%) without affecting COX-2 gene expression in LPS-stimulated THP-1 cells. The extracts demonstrated prominent in vivo anti-inflammatory potential upon oral administration in rats. Especially FVA extract at 100 and 200 mg/kg significantly inhibited carrageenan-induced edema formation. From these results, it can be concluded that F. vulgaris extracts possess interesting anti-inflammatory properties.

Filipendula vulgaris Moench（dropwort）在传统医学中用于缓解各种炎症相关疾病。在本研究中，植物化学物质分布F.寻常地上部分（FVA）和根（FVR）甲醇提取物通过LC-DAD-HRMS分析评价。此外，评估了它们的体外和体内抗炎作用以及潜在的细胞毒性。结果表明，提取物主要含有酚类物质，如黄酮类化合物，可水解单宁，原花青素和酚酸衍生物，其中包括高果胶。没有体外发现最高浓度（50μg/ mL）的细胞毒性。FVA提取物（50μg/ mL）在体外显着抑制环氧合酶-1和-2（COX-1和COX-2）的活性（> 50％抑制），FVR提取物显着抑制COX-2的活性（52.5±2.7％）不会影响LPS刺激的THP-1细胞中COX-2基因的表达。提取物在大鼠口服后显示出显着的体内抗炎潜力。特别是100和200 mg / kg的FVA提取物可显着抑制角叉菜胶诱导的水肿形成。从这些结果，可以得出结论，寻常豆提取物具有有趣的抗炎特性。