The potential health benefit of dietary fiber has attracted considerable attention in recent decades. In this study, the effects of modified dietary fibers (MDF) derived from okara on body composition, fat distribution, serum metabolomic parameters, and fatty acid profiles in mice fed high-fat diets (HFD) were evaluated by nuclear magnetic resonance (NMR)-based metabolic approach. HFD-induced C57BL mice were fed with a diet containing 100 g/kg MDF for 12 weeks. Compared with control mice, MDF-fed mice exhibited less fat and lower body weights, altered serum metabolomic profiles, and distinct fatty acid profiles. The levels of choline, phosphatidylcholine, glycerophosphorylcholine, glucose, lysine, scyllo-inositol, and glutamate for MDF group were higher than those for both CONT and HFD groups. A remarkable reduction of total cholesterol, total triglycerides, ω-6 fatty acids, alanine, citrate, creatine, or succinate was also observable for MDF group compared with HFD group. These findings demonstrated that the intake of MDF derived from okara clearly ameliorated some of the HFD-induced adverse metabolic effects and prevented adipose tissue accumulation.

近几十年来，膳食纤维的潜在健康益处引起了广泛关注。在这项研究中，通过核磁共振（NMR）评估了来自豆渣的改性膳食纤维（MDF）对高脂饮食（HFD）小鼠的身体成分、脂肪分布、血清代谢参数和脂肪酸谱的影响基于代谢的方法。 HFD 诱导的 C57BL 小鼠用含有 100 g/kg MDF 的饮食喂养 12 周。与对照小鼠相比，MDF 喂养的小鼠表现出较少的脂肪和较低的体重、改变的血清代谢谱和不同的脂肪酸谱。 MDF组的胆碱、磷脂酰胆碱、甘油磷酰胆碱、葡萄糖、赖氨酸、鲨肌醇和谷氨酸水平高于CONT组和HFD组。与 HFD 组相比，MDF 组的总胆固醇、总甘油三酯、ω-6 脂肪酸、丙氨酸、柠檬酸盐、肌酸或琥珀酸盐也显着降低。这些研究结果表明，摄入来自豆渣的中密度纤维板可以明显改善一些高脂饮食引起的不良代谢效应，并防止脂肪组织积累。