Stroke is one of the leading causes of death worldwide, and the majority of cerebral stroke is caused by occlusion of cerebral circulation, which eventually leads to brain infarction. Although stroke occurs mainly in the aged population, most animal models for experimental stroke in vivo almost universally rely on young-adult rodents for the evaluation of neuropathological, neurological, or behavioral outcomes after stroke due to their greater availability, lower cost, and fewer health problems. However, it is well established that aged animals differ from young animals in terms of physiology, neurochemistry, and behavior. Stroke-induced changes are more pronounced with advancing age. Therefore, the overlooked role of age in animal models of stroke could have an impact on data quality and hinder the translation of rodent models to humans. In addition to aging, other factors also influence functional performance after ischemic stroke. In this article, we summarize the differences between young and aged animals, the impact of age, sex and animal strains on performance and outcome in animal models of stroke and emphasize age as a key factor in preclinical stroke studies.

中文翻译：

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年龄，性别和品系对中风动物模型的性能和结果的影响。

中风是世界范围内主要的死亡原因之一，而大多数脑中风是由于大脑循环的阻塞所致，最终导致脑梗塞。尽管中风主要发生在老年人群中，但是大多数用于体内实验性中风的动物模型几乎都依赖于成年啮齿动物来评估中风后的神经病理，神经或行为结果，因为它们的可用性更高，成本更低且健康状况更差问题。但是，众所周知，老年动物在生理学，神经化学和行为方面与幼小动物不同。随着年龄的增长，中风引起的变化更加明显。因此，年龄在中风动物模型中被忽视的作用可能会影响数据质量并阻碍啮齿动物模型向人类的转化。除老化外，其他因素也影响缺血性中风后的功能表现。在本文中，我们总结了中老年动物之间的差异，年龄，性别和动物品系对中风动物模型的性能和结果的影响，并强调年龄是临床前中风研究的关键因素。