New Friedel–Crafts strategy for preparing 3-acylindoles,Organic & Biomolecular Chemistry

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New Friedel–Crafts strategy for preparing 3-acylindoles
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2018-10-03 , DOI: 10.1039/c8ob02094a
Lian-Hua Li _{1,

2,

3,

4,

5} , Zhi-Jie Niu _{1,

2,

3,

4,

5} , Yong-Min Liang _{1,

2,

3,

4,

5}

Affiliation

A selective Friedel–Crafts acylation of indoles via an unusual cleavage of the amide C–N bond was achieved by triflic anhydride activation. This method offers rapid efficient access to high-biological-value 3-acylindoles, performs a series of scrupulous mechanistic studies and offers a strong courage that amide synthons can form new C–C bonds under transition-metal-free conditions.

中文翻译：

制备3-acylindoles的新Friedel-Crafts策略

吲哚的选择性Friedel-Crafts酰化经由酰胺C-N键的一个不寻常的裂解物通过三氟甲磺酸酐的活化来实现。这种方法可以快速有效地获得具有高生物价值的3-acylindoles，进行了一系列严格的机理研究，并提供了强大的勇气，即酰胺合成子可以在无过渡金属的条件下形成新的C-C键。

更新日期：2018-11-02

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