Sensing caspase-1 activity using activatable 19F MRI nanoprobes with improved turn-on kinetics†,Chemical Communications

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Sensing caspase-1 activity using activatable 19F MRI nanoprobes with improved turn-on kinetics†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-10-02 00:00:00 , DOI: 10.1039/c8cc05381b
Kazuki Akazawa _{1,

2,

3,

4,

5} , Fuminori Sugihara _{3,

4,

5,

6} , Masafumi Minoshima _{1,

2,

3,

4,

5} , Shin Mizukami _{5,

7,

8,

9} , Kazuya Kikuchi _{1,

2,

3,

4,

5}

Affiliation

Activatable ¹⁹F MRI nanoprobes for sensing caspase-1 activity were developed. Tandem repetition of substrate peptide sequences improved the turn-on response of nanoprobes, allowing detection of caspase-1 activity by ¹⁹F MRI. In vivo immune response was successfully imaged using the new nanoprobe.

中文翻译：

使用可活化的¹⁹ F MRI纳米探针检测caspase-1活性，并改善了启动动力学†

开发了可激活的¹⁹ F MRI纳米探针，用于检测caspase-1的活性。串联重复的底物肽序列改善了纳米探针的开启响应，从而允许通过¹⁹ F MRI检测caspase-1活性。使用新的纳米探针成功成像了体内免疫反应。

更新日期：2018-10-02

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