An ESIPT Probe for the Ratiometric Imaging of Peroxynitrite Facilitated by Binding to Aβ-Aggregates,Journal of the American Chemical Society

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An ESIPT Probe for the Ratiometric Imaging of Peroxynitrite Facilitated by Binding to Aβ-Aggregates
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2018-10-02 , DOI: 10.1021/jacs.8b08457
Adam C. Sedgwick _{1,

2} , Wei-Tao Dou ₃ , Jin-Biao Jiao ₃ , Luling Wu ₁ , George T. Williams ₁ , A. Toby A. Jenkins ₁ , Steven D. Bull ₁ , Jonathan L. Sessler ₂ , Xiao-Peng He ₃ , Tony D. James _{1,

4}

Affiliation

A series of 3-hydroxyflavone (3-HF) ESIPT (excited-state intramolecular proton transfer) boronate-based fluorescent probes have been developed for the detection of peroxynitrite (ONOO-). The dyes are environmentally sensitive, and each probe exhibited a ratiometric response toward ONOO- in a micellar environment. The probes were used to image different aggregation states of amyloid-β (Aβ) in the presence of ONOO-. The 3-HF-OMe probe was found to produce a ratiometric response toward ONOO- when bound to Aβ aggregates, resulting in a novel host-guest ensemble, which adds insight into the development of other ESIPT-based probes for the simultaneous sensing of fibrous proteins/peptides and environmental ROS/RNS.

中文翻译：

用于通过与 Aβ-聚集体结合促进过氧亚硝酸盐的比例成像的 ESIPT 探针

已经开发了一系列基于 3-羟基黄酮 (3-HF) ESIPT（激发态分子内质子转移）硼酸盐的荧光探针，用于检测过氧亚硝酸盐 (ONOO-)。染料对环境敏感，每个探针在胶束环境中对 ONOO- 表现出比例响应。探针用于在 ONOO- 存在下对淀粉样蛋白-β (Aβ) 的不同聚集状态进行成像。发现 3-HF-OMe 探针与 Aβ 聚集体结合时会产生对 ONOO- 的比率响应，从而形成一种新的主客体集合，这增加了对其他基于 ESIPT 的探针的开发的深入了解，用于同时感测纤维蛋白质/肽和环境 ROS/RNS。

更新日期：2018-10-02

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