Clenbuterol (CLB) is harmful to human health when used long term, and it has been listed by the World Anti-Doping Agency (WADA). In this work, a novel zinc-based metal-organic frameworks–reduced graphene oxide–CdTe quantum dots (ZnMOF-RGO-CdTe QDs) hybrid was used to construct an electrochemiluminescence (ECL) sensor for detecting CLB. CdTe QDs, loaded by RGO, exhibited an enhanced ECL signal. In addition, the ZnMOFs catalyzed OH^• generation by coreactant H₂O₂, which further strengthened the ECL signal of the CdTe QDs. The integration of ZnMOFs and RGO-CdTe QDs endowed the sensor with high sensitivity for CLB detection. The intensity of the ECL signal increased as the concentration of CLB increased. The linear range of CLB detection was 3.0 × 10⁻¹³ M to 6.0 × 10⁻¹⁰ M, and the detection limit was estimated to be 1.0 × 10⁻¹³ M. Furthermore, the sensor displayed a good repeatability and stability. The ZnMOF-RGO-CdTe QD hybrids described in this study provide a foundation for the development of new methods of detecting CLB.

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长期服用瘦肉精（CLB）对人体健康有害，并且已被世界反兴奋剂机构（WADA）列出。在这项工作中，一种新型的基于锌的金属-有机骨架-还原的氧化石墨烯-CdTe量子点（ZnMOF-RGO-CdTe QDs）杂合物被用于构建用于检测CLB的电化学发光（ECL）传感器。由RGO加载的CdTe QD表现出增强的ECL信号。另外，ZnMOFs通过共反应剂H ₂ O ₂催化了OH ^•的产生，从而进一步增强了CdTe QDs的ECL信号。ZnMOF和RGO-CdTe QD的集成使该传感器对CLB检测具有很高的灵敏度。ECL信号的强度随CLB浓度的增加而增加。CLB检测的线性范围为3.0×10^-13  M至6.0×10 ^-10  M，检测极限估计为1.0×10 ^-13M  。此外，该传感器具有良好的重复性和稳定性。这项研究中描述的ZnMOF-RGO-CdTe QD杂种为开发检测CLB的新方法提供了基础。

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