Manganese-Catalyzed α-Alkylation of Ketones, Esters, and Amides Using Alcohols.,ACS Catalysis

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Manganese-Catalyzed α-Alkylation of Ketones, Esters, and Amides Using Alcohols.
ACS Catalysis ( IF 11.3 ) Pub Date : 2018-10-02 , DOI: 10.1021/acscatal.8b03720
Subrata Chakraborty ₁ , Prosenjit Daw ₁ , Yehoshoa Ben David ₁ , David Milstein ₁

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Herein we report the manganese-catalyzed C-C bond-forming reactions via α-alkylation of ketones, amides, and esters, using primary alcohols. β-Alkylation of secondary alcohols by primary alcohols to obtain α-alkylated ketones is also reported. The reactions are catalyzed by a ( i Pr-PNP)Mn(H)(CO)2 pincer complex under mild conditions in the presence of (catalytic) base liberating water (and H2 in the case of secondary alcohol alkylation) as the sole byproduct.

中文翻译：

用醇锰催化的酮，酯和酰胺的α-烷基化反应。

在本文中，我们报告了使用伯醇通过酮，酰胺和酯的α-烷基化反应锰催化的CC键形成反应。还报道了伯醇通过仲醇的β-烷基化反应而获得α-烷基化的酮。该反应是由（i Pr-PNP）Mn（H）（CO）2钳配合物在温和条件下以（催化）碱释放水（在仲醇烷基化的情况下为H2）作为唯一副产物的条件下催化的。

更新日期：2018-10-02

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