Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery,Bioconjugate Chemistry

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Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2018-10-01 00:00:00 , DOI: 10.1021/acs.bioconjchem.8b00603
Rafael R. Castillo _{1,

2} , Daniel Lozano _{1,

2} , María Vallet-Regí _{1,

2,

3}

Affiliation

Despite the claim that encapsulation of drugs improves the therapeutic profile of free drugs, there are still important limitations in drug delivery. With respect to cancer treatment, two promising implementations are combination therapy and targeted devices, which are aimed at increasing the drug effect either by achieving higher cell death rates or by discriminating between cell populations. However, for the time being, the scope of combining both approaches is unknown. To advance this knowledge, a two-drug-delivery system with dual cell-organelle targeting based on mesoporous silica nanoparticles, which are known to be able to host drugs within their pores, has been designed. In vitro results show a synergistic effect and high efficacy, demonstrating that the combination of dual therapy and targeting could still advance the development of drug-delivery nanodevices against difficult-to-treat cancers.

中文翻译：

基于构件的膜-器官双靶纳米系统用于两种药物输送的构建。

尽管声称封装药物可以改善游离药物的治疗效果，但药物传递仍然存在重要的局限性。关于癌症治疗，两种有希望的实现方式是联合疗法和靶向装置，其旨在通过实现更高的细胞死亡率或通过区分细胞群来提高药物作用。但是，暂时还不知道将这两种方法结合起来的范围。为了提高这一知识，已经设计了一种基于介孔二氧化硅纳米粒子的双细胞器靶向双药递送系统，已知该介孔二氧化硅纳米粒子能够在其孔中容纳药物。体外结果显示出协同作用和高功效，表明双重疗法和靶向疗法的组合仍可促进针对难以治疗的癌症的药物递送纳米装置的开发。

更新日期：2018-10-01

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