On-chip photodynamic therapy – monitoring cell metabolism using electrochemical microsensors,Lab on a Chip

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On-chip photodynamic therapy – monitoring cell metabolism using electrochemical microsensors
Lab on a Chip ( IF 6.1 ) Pub Date : 2018-10-02 00:00:00 , DOI: 10.1039/c8lc00799c
Julia Marzioch _{1,

2,

3,

4} , Jochen Kieninger _{1,

2,

3,

4} , Andreas Weltin _{1,

2,

3,

4} , Hubert Flamm _{1,

2,

3,

4} , Kuppusamy Aravindalochanan _{1,

2,

3,

4} , Joe A. Sandvik _{5,

6,

7} , Erik O. Pettersen _{5,

6,

7} , Qian Peng _{7,

8,

9,

10} , Gerald A. Urban _{1,

2,

3,

4}

Affiliation

We introduce a new system which combines metabolic monitoring using electrochemical microsensors with photodynamic therapy on-chip for the first time. Oxygen consumption of T-47D breast cancer cells was measured during therapy with protoporphyrin IX. We determined the efficacy of the therapy and revealed its recovery effects, which underlines the high relevance of continuous monitoring.

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