Noncovalent spin-labeling of RNA: the aptamer approach†,Chemical Communications

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Noncovalent spin-labeling of RNA: the aptamer approach†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-10-02 00:00:00 , DOI: 10.1039/c8cc05597a
Subham Saha _{1,

2,

3} , Thilo Hetzke _{4,

5,

6} , Thomas F. Prisner _{4,

5,

6} , Snorri Th. Sigurdsson _{1,

2,

3}

Affiliation

In the first example of site-directed spin-labeling of unmodified RNA, a pyrrolidine-nitroxide derivative of tetramethylrosamine (TMR) was shown to bind with high affinity to the malachite green (MG) aptamer, as determined by continuous-wave (CW) electron paramagnetic resonance (EPR), pulsed electron–electron double resonance (PELDOR) and fluorescence spectroscopies.

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