Background

Genetic and environmental risk factors have been associated with the development of multiple primary melanomas (MPMs). We hypothesized that individuals with MPMs might have an increased incidence of internal malignancies.

Objective

To identify the risk for subsequent malignancies in MPM patients.

Methods

Multiple primary standardized incidence ratios were analyzed for individuals with ≥1, ≥2 and ≥3 primary melanomas (PMs) recorded in the Surveillance, Epidemiology, and End Results database during 1973-2014.

Results

We identified 223,799 individuals with ≥1 PM, 19,709 with ≥2 PMs, and 3,995 with ≥3 PMs. Risks of subsequent internal malignancy increased with number of PMs, with observed:expected ratios of 0.99, 1.14, and 1.23 (P < .05) for patients with ≥1 PM, ≥2 PMs, and ≥3 PMs, respectively. Internal malignancy was higher in younger MPM patients and those with superficial spreading melanoma. The most common malignancies among MPM patients included breast, prostate, thyroid, soft tissue, brain, kidney, non-Hodgkin lymphoma, and chronic lymphocytic leukemia. Risk for subsequent cutaneous melanoma increased with observed:expected ratios of 8.09, 22.52, 41.03 (P < .05) for patients with ≥1 PM, ≥2 PMs, and ≥3 PMs, respectively.

Limitations

Surveillance, Epidemiology, and End Results records limited information about pigmentation phenotypes, histology, and treatments.

Conclusion

Patients with MPMs have an increased risk for subsequent internal and cutaneous malignancies and might benefit from tight adherence to age-specific cancer screening.

中文翻译：

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多原发性黑色素瘤与恶性风险的关联：对 1973-2014 年监测、流行病学和最终结果计划数据库中条目的基于人群的分析

背景

遗传和环境风险因素与多原发性黑色素瘤 (MPM) 的发展有关。我们假设患有 MPM 的个体体内恶性肿瘤的发病率可能增加。

客观的

确定 MPM 患者随后发生恶性肿瘤的风险。

方法

对 1973-2014 年监测、流行病学和最终结果数据库中记录的≥1、≥2 和≥3 原发性黑色素瘤 (PM) 的个体的多个初级标准化发病率进行了分析。

结果

我们确定了 223,799 名 PM ≥ 1 人、19,709 人 PM ≥ 2 人和 3,995 人 PM ≥ 3 人。 随后发生内部恶性肿瘤的风险随着 PM 数量的增加而增加，对于 ≥ 1 个 PM、≥ 2 个 PM 和 ≥ 3 个 PM 的患者，观察到的：预期比率分别为 0.99、1.14 和 1.23 ( P < .05)。年轻的 MPM 患者和浅表扩散性黑色素瘤患者的内部恶性肿瘤发生率更高。MPM 患者中最常见的恶性肿瘤包括乳腺癌、前列腺癌、甲状腺癌、软组织癌、脑癌、肾癌、非霍奇金淋巴瘤和慢性淋巴细胞白血病。 对于 PM ≥ 1 次、PM ≥ 2 次和 PM ≥ 3 次的患者，随后发生皮肤黑色素瘤的风险 增加，观察到的：预期比率分别为 8.09、22.52、41.03 ( P < .05)。

限制

监测、流行病学和最终结果记录了有关色素沉着表型、组织学和治疗的有限信息。

结论

MPMs 患者随后发生内部和皮肤恶性肿瘤的风险增加，并且可能受益于严格遵守特定年龄的癌症筛查。