BACKGROUND Promising results with platelet-rich plasma (PRP) in androgenetic alopecia that could be associated with platelet number and growth factor levels were described. OBJECTIVE Analyze the platelet countand growth factor levels in PRP and their correlation with hair growth parameters evaluated by using the TrichoScan (Tricholog GmbH, Freiburg, Germany). METHODS A total of 26 patients were randomized to receive 4 subcutaneous injections of PRP or saline. Hair growth, hair density, and percentage of anagen hairs were evaluated by using the TrichoScan method before injection, 15 days after the last injection, and again 3 months after the last injection. Growth factors (platelet-derived growth factor, epidermal growth factor, and vascular endothelial growth factor) were measured by the Luminex method (Millipore, Bedford, MA). RESULTS We demonstrated a significant increase in hair count (P = .0016), hair density (P = .012) and percentage of anagen hairs (P = .007) in the PRP group versus in the control group, without correlation with platelet counts or quantification of the growth factors in PRP. LIMITATIONS Other growth factors that could be related to response to PRP were not evaluated. CONCLUSION Our data favor the use of PRP as a therapeutic alternative in the treatment of androgenetic alopecia. The lack of association between platelet count, platelet-derived growth factor, epidermal growth factor, and vascular endothelial growth factor levels and clinical improvement suggest that other mechanisms could be involved in this response.

中文翻译：

---

用富含血小板的血浆治疗男性型脱发：一项双盲对照研究，分析了血小板数量和生长因子水平。

背景技术描述了雄激素性脱发中富含血小板的血浆（PRP）的有希望的结果，该结果可能与血小板数量和生长因子水平有关。目的分析使用TrichoScan（Tricholog GmbH，弗莱堡，德国）评估的PRP中的血小板计数和生长因子水平及其与毛发生长参数的相关性。方法将26例患者随机分为4例皮下注射PRP或生理盐水。在注射前，最后一次注射后15天和最后一次注射后3个月，使用TrichoScan方法评估头发的生长，头发密度和毛发生长毛的百分比。生长因子（血小板衍生的生长因子，表皮生长因子和血管内皮生长因子）通过Luminex方法（密理博，贝德福德，马萨诸塞州）进行测量。结果我们证明，与对照组相比，PRP组的毛发计数（P = .0016），毛发密度（P = .012）和生毛百分比（P = .007）显着增加，与血小板计数没有相关性或量化PRP中的生长因子。局限性未评估可能与对PRP反应有关的其他生长因子。结论我们的数据支持使用PRP作为雄激素性脱发的替代治疗方法。血小板计数，血小板衍生生长因子，表皮生长因子和血管内皮生长因子水平与临床改善之间缺乏关联，这表明其他机制可能与该反应有关。007）PRP组与对照组相比，与血小板计数或PRP中生长因子的定量无关。局限性未评估可能与对PRP反应有关的其他生长因子。结论我们的数据支持使用PRP作为雄激素性脱发的替代治疗方法。血小板计数，血小板衍生生长因子，表皮生长因子和血管内皮生长因子水平与临床改善之间缺乏关联，这表明其他机制可能与该反应有关。007）PRP组与对照组相比，与血小板计数或PRP中生长因子的定量无关。局限性未评估可能与对PRP反应有关的其他生长因子。结论我们的数据支持使用PRP作为雄激素性脱发的替代治疗方法。血小板计数，血小板衍生生长因子，表皮生长因子和血管内皮生长因子水平与临床改善之间缺乏关联，这表明其他机制可能与该反应有关。结论我们的数据支持使用PRP作为雄激素性脱发的替代治疗方法。血小板计数，血小板衍生生长因子，表皮生长因子和血管内皮生长因子水平与临床改善之间缺乏关联，这表明其他机制可能与该反应有关。结论我们的数据支持使用PRP作为雄激素性脱发的替代治疗方法。血小板计数，血小板衍生生长因子，表皮生长因子和血管内皮生长因子水平与临床改善之间缺乏关联，这表明其他机制可能与该反应有关。