Rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray ionization mass spectrometry,Journal of Food and Drug Analysis

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Rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray ionization mass spectrometry
Journal of Food and Drug Analysis ( IF 2.6 ) Pub Date : 2019-04-01 , DOI: 10.1016/j.jfda.2018.09.002
Tsz-Tsun Ng _{1,

2} , Pui-Kin So _{1,

2} , Bin Hu _{1,

2,

3} , Zhong-Ping Yao _{1,

2}

Affiliation

Determination of drugs-of-abuse in body fluids of drug abusers is important for the law enforcement as well as the treatment and rehabilitation. In this study, wooden-tip electrospray ionization mass spectrometry (WT-ESI-MS), a simple and cost-effective technique, was developed for rapid detection and quantitation of common drugs-of-abuse, including methamphetamine, methylenedioxymethamphetamine (MDMA), cocaine, heroin and tetrahydrocannabinol (THC), in urine and oral fluid, following our previous successful demonstration for rapid and sensitive detection of ketamine and nor-ketamine in urine and oral fluid by this technique. It was found that the limit-of-detection for methamphetamine could fully fulfill the cut-off value requirements of the international standards, and those of MDMA and cocaine could fulfill some of the requirements. The linear range, accuracy and precision for quantitation of the drugs were generally satisfactory, except for THC for which the analytical performance still needs to be improved. Analysis of one sample could typically be completed within minutes. These results indicated that WT-ESI-MS could be used for rapid screening of drugs-of-abuse in urine, oral fluid as well as other body fluids.

中文翻译：

木尖电喷雾离子质谱法快速检测和定量滥用药物

确定吸毒者体液中的滥用药物对于执法以及治疗和康复具有重要意义。在这项研究中，开发了一种简单且经济高效的木尖电喷雾电离质谱 (WT-ESI-MS) 技术，用于快速检测和定量常见滥用药物，包括甲基苯丙胺、亚甲二氧基甲基苯丙胺 (MDMA)、继我们之前成功演示了通过该技术快速灵敏地检测尿液和口腔液中的氯胺酮和去甲氯胺酮后，尿液和口腔液中的可卡因、海洛因和四氢大麻酚 (THC)。发现甲基苯丙胺的检测限完全满足国际标准的临界值要求，摇头丸和可卡因的检测限可以满足部分要求。药物定量的线性范围、准确度和精密度总体上令人满意，但四氢大麻酚的分析性能仍有待提高。一个样品的分析通常可以在几分钟内完成。这些结果表明，WT-ESI-MS 可用于快速筛查尿液、口腔液以及其他体液中的滥用药物。

更新日期：2019-04-01

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