Viedma ripening is an emerging method for the solid‐phase deracemization of mixtures of enantiomers. Up to now, the scope of the method has remained limited to molecules with a single stereocenter. We show here that this method can be extended to obtain a single enantiomer from a mixture of stereoisomers with two different stereocenters. In addition, we show that by using tailor‐made chiral additives, the conversion time can be reduced by a factor of 100.

中文翻译：

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四种立体异构体的固相转化为单个对映异构体

Viedma成熟是对映异构体混合物进行固相脱硫的新兴方法。迄今为止，该方法的范围仍然限于具有单个立体中心的分子。我们在这里表明，该方法可以扩展为从具有两个不同立体中心的立体异构体混合物中获得单个对映异构体。此外，我们证明，通过使用量身定制的手性添加剂，转化时间可以减少100倍。