Photomodulated Nanozyme Used for a Gram-Selective Antimicrobial,Chemistry of Materials

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Photomodulated Nanozyme Used for a Gram-Selective Antimicrobial
Chemistry of Materials ( IF 7.2 ) Pub Date : 2018-10-01 00:00:00 , DOI: 10.1021/acs.chemmater.8b02365
Jingsheng Niu _{1,

2} , Yuhuan Sun _{1,

2} , Faming Wang _{1,

3} , Chuanqi Zhao ₁ , Jinsong Ren ₁ , Xiaogang Qu ₁

Affiliation

Although broad-spectrum antibacterial agents have been developed for antibacterial treatment, the balance of microbial flora may break and this usually results in increasing resistance. To this end, developing simple and effective strain-selective bactericidal strategies are demanding. Herein we designed an intelligent Gram-selective antimicrobial system based on MoS₂ and a photoacid molecule. This system can be modulated by light for surface charge conversion from negative to positive and simultaneously activation of the enzymatic activity of MoS₂ by changing pH. In consideration of the different cell wall composition and structures of bacterial strains, Gram-selective antibacterial has been accomplished simply by controlling the light irradiation time. Taken together, we provided a simple and efficient photoregulated method to realize strain-selective antibacterial.

中文翻译：

用于革兰氏选择性抗菌的光调节纳米酶

尽管已经开发了用于抗菌治疗的广谱抗菌剂，但微生物菌群的平衡可能会破坏，这通常会导致耐药性的提高。为此，需要开发简单有效的菌株选择性杀菌策略。本文中，我们基于MoS ₂和光酸分子设计了一种智能的革兰氏选择性抗菌系统。该系统可以通过光进行调制，以将表面电荷从负转换为正，并同时激活MoS ₂的酶活性通过改变pH值。考虑到不同的细胞壁组成和细菌菌株的结构，仅通过控制光照射时间即可完成革兰氏选择性抗菌。综上所述，我们提供了一种简单有效的光调节方法来实现菌株选择性抗菌。

更新日期：2018-10-01

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