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Biodegradable and Renal-Clearable Hollow Porous Iron Oxide Nanoboxes for in Vivo Imaging
Chemistry of Materials ( IF 7.2 ) Pub Date : 2018-10-01 00:00:00 , DOI: 10.1021/acs.chemmater.8b03564 Ruixue Wei 1 , Zhongyuan Cai 2 , Bin W. Ren 1 , Ao Li 1 , Hongyu Lin 1 , Ke Zhang 3 , Hongming Chen 1 , Hong Shan 3 , Hua Ai 2 , Jinhao Gao 1
Chemistry of Materials ( IF 7.2 ) Pub Date : 2018-10-01 00:00:00 , DOI: 10.1021/acs.chemmater.8b03564 Ruixue Wei 1 , Zhongyuan Cai 2 , Bin W. Ren 1 , Ao Li 1 , Hongyu Lin 1 , Ke Zhang 3 , Hongming Chen 1 , Hong Shan 3 , Hua Ai 2 , Jinhao Gao 1
Affiliation
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For in vivo imaging, it is important that imaging agents could be harmlessly eliminated from the body after performing their functions. Gadolinium-based magnetic resonance contrast agents have been suffering from low relaxivity, a potential risk of gadolinium deposition. The biocompatibility and biodegradability of γ-Fe2O3 nanoparticles render them promising as a potential candidate contrast agent for MRI applications. Herein, we develop a facile synthesis of biodegradable hollow porous iron oxide nanoboxes (HPIOs) with high r1 values and low r2/r1 ratios, allowing for superior contrast-enhanced T1 imaging. The zwitterionic dopamine sulfonate (ZDS) functionalized HPIOs ([email protected]) could effectively avoid nonspecific protein adsorption and achieve controllable biodistribution. Furthermore, [email protected] could be degraded into 4–5 nm fragments in the body and subsequently cleared by kidneys rapidly after magnetic resonance imaging, which significantly reduces potential long-term toxicity. These desirable features make [email protected] a prominent T1 contrast agent for magnetic resonance angiography in vivo. These biodegradable and biocompatible [email protected] holds great promise for highly sensitive and accurate detection of heart and vascular diseases in molecular imaging.
中文翻译：
可体内降解的可清除肾脏的空心多孔氧化铁纳米盒
对于体内成像，重要的是成像剂在执行其功能后可以无害地从体内清除。d基磁共振造影剂的弛豫度低，这是ado沉积的潜在风险。生物相容性和γ -铁的生物降解性2 ö 3纳米颗粒使得它们有希望作为一种潜在的候选造影剂用于MRI应用。本文中，我们开发了一种易于合成的具有高r 1值和低r 2 / r 1比的可生物降解的中空多孔氧化铁纳米盒（HPIOs），从而可实现出色的对比度增强T 1成像。两性离子多巴胺磺酸盐（ZDS）功能化的HPIOs（[受电子邮件保护]）可以有效避免非特异性蛋白质吸附并实现可控的生物分布。此外，[电子邮件保护的]可能会在体内降解为4-5 nm碎片，然后在磁共振成像后被肾脏迅速清除，这大大降低了潜在的长期毒性。这些理想的功能使[电子邮件保护]成为体内磁共振血管造影的重要T 1造影剂。这些可生物降解和生物相容性[受电子邮件保护]在分子成像中高度灵敏和准确地检测心脏和血管疾病具有广阔的前景。
更新日期：2018-10-01
中文翻译：
可体内降解的可清除肾脏的空心多孔氧化铁纳米盒
对于体内成像，重要的是成像剂在执行其功能后可以无害地从体内清除。d基磁共振造影剂的弛豫度低，这是ado沉积的潜在风险。生物相容性和γ -铁的生物降解性2 ö 3纳米颗粒使得它们有希望作为一种潜在的候选造影剂用于MRI应用。本文中，我们开发了一种易于合成的具有高r 1值和低r 2 / r 1比的可生物降解的中空多孔氧化铁纳米盒（HPIOs），从而可实现出色的对比度增强T 1成像。两性离子多巴胺磺酸盐（ZDS）功能化的HPIOs（[受电子邮件保护]）可以有效避免非特异性蛋白质吸附并实现可控的生物分布。此外，[电子邮件保护的]可能会在体内降解为4-5 nm碎片，然后在磁共振成像后被肾脏迅速清除，这大大降低了潜在的长期毒性。这些理想的功能使[电子邮件保护]成为体内磁共振血管造影的重要T 1造影剂。这些可生物降解和生物相容性[受电子邮件保护]在分子成像中高度灵敏和准确地检测心脏和血管疾病具有广阔的前景。
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