Scalable In-Fiber Manufacture of Functional Composite Particles,ACS Nano

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Scalable In-Fiber Manufacture of Functional Composite Particles
ACS Nano ( IF 15.8 ) Pub Date : 2018-09-28 00:00:00 , DOI: 10.1021/acsnano.8b05560
Minghui Du _{1,

2} , Shubiao Ye ₃ , Junzhou Tang _{1,

2} , Shichao Lv _{1,

2} , Jiejie Chen _{1,

2} , Jiri Orava ₄ , Guangming Tao ₅ , Ping Lan ₃ , Jianhua Hao ₆ , Zhongmin Yang _{1,

2} , Jianrong Qiu ₇ , Shifeng Zhou _{1,

2}

Affiliation

Advanced fabrication methods must be developed for magnetic–polymeric particles, which are used in medical diagnostics, drug delivery, separation, and environmental remediation. The development of scalable fabrication processes that enables simultaneously tuning of diameters and compositions of magnetic–polymeric particles remains a major challenge. Here, we proposed the production of high-quality magnetic-composite particles through a universal method based on the in-fiber Plateau–Rayleigh instability of polymeric fibers. This method can simultaneously control the particle diameter, hybrid configuration, and functional properties. The diameter of magnetic–polymeric particles can be reproducibly tuned from ∼20 nm to 1.25 mm, a wide range unachievable by conventional solution methods. The final diameter was controlled by the inner/outer fiber diameter ratio. We further showed that the prepared magnetic–polymeric composite particles can be used for the highly efficient recovery of heavy metals (98.2% for Cd²⁺) and for the precise separation of immune cells (CD4⁺ T cells). Overall, the in-fiber manufacture method can become a universal technology for the scalable preparation of different types of magnetic–polymeric composite particles with diverse functionalities.

中文翻译：

功能性复合颗粒的可扩展纤维内生产

必须开发用于磁性聚合物颗粒的先进制造方法，这些方法可用于医学诊断，药物输送，分离和环境修复。可伸缩制造工艺的发展使得能够同时调节磁性聚合物颗粒的直径和组成仍然是一个重大挑战。在这里，我们基于聚合物纤维在纤维内的高原-瑞利不稳定性，提出了一种通过通用方法生产高品质磁性复合颗粒的方法。该方法可以同时控制粒径，杂化构型和功能特性。磁性聚合物颗粒的直径可以可重复地从约20 nm调整到1.25 mm，这是常规溶液方法无法实现的。最终直径由内/外纤维直径比控制。我们进一步表明，制备的磁性聚合物复合颗粒可用于高效重金属的回收（镉的98.2％²⁺）和精确分离免疫细胞（CD4 ⁺ T细胞）。总的来说，纤维内制造方法可以成为可扩展地制备具有不同功能的不同类型的磁性聚合物复合颗粒的通用技术。

更新日期：2018-09-28

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