Biopharmaceutical industry is presently facing multiple economic, political and regulatory challenges. The adoption of continuous bioprocessing is expected to partly alleviate these. Over the years, many technology solutions have been developed for various biotech unit operations which were hitherto operated in batch fashion. The next challenge is to integrate all unit operations to create a fully continuous manufacturing system. In this article, we discuss recent developments in process integration and control under a proposed framework consisting of modular, adaptation and merger approaches of integration with a particular emphasis on developments that have occurred in the past five years (2013–2018).

生物制药行业目前正面临着多种经济，政治和监管挑战。连续生物处理的采用有望部分缓解这些问题。多年来，已经为迄今以批处理方式操作的各种生物技术单元操作开发了许多技术解决方案。下一个挑战是整合所有部门的运营，以创建一个完全连续的制造系统。在本文中，我们讨论了在提议的框架下过程集成和控制的最新发展情况，该框架由模块化，适应性和合并合并方法组成，并特别强调了过去五年（2013-2018年）中发生的发展。