Rosmarinic acid is a bioactive phytochemical that can be found in many herbs as ethnomedicines. It possesses remarkable pharmacological activities, and thus leading to its exploration as a therapeutic drug in diabetes treatment recently. This article reviews the extraction and fractionation techniques for plant-based natural rosmarinic acid and its anti-diabetic potential based on literature data published in journals, books, and patents from 1958 to 2017. Factors affecting the performance of rosmarinic acid extraction and fractionation such as operating temperature, time, solvent to sample ratio and eluent system are compiled and discussed in detail. The inhibitory action of rosmarinic acid against sugar digestive enzymes, and protective action towards pancreatic β-cell dysfunction and glucolipotoxicity mediated oxidative stress are also critically reviewed. The optimal parameters are largely dependent on the applied extraction and fractionation techniques, as well as the nature of plant samples. Previous studies have proven the potent role of rosmarinic acid to control plasma glucose level and increase insulin sensitivity in hyperglycemia. Although rosmarinic acid is readily absorbed by human body, its mechanism after consumption is remained unclear. Intensive studies should be well planned to determine the dosage and toxicity level of rosmarinic acid for efficacy and safe consumption.

迷迭香酸是一种具有生物活性的植物化学物质，在许多草药中都可以作为民族药。它具有非凡的药理活性，因此最近被探索为糖尿病治疗中的治疗药物。本文根据1958年至2017年发表在期刊，书籍和专利中的文献数据，综述了植物性天然迷迭香酸的提取和分离技术及其抗糖尿病潜力。影响迷迭香酸提取和分离性能的因素包括：汇编并详细讨论了操作温度，时间，溶剂与样品的比例以及洗脱液系统。迷迭香酸对糖消化酶的抑制作用，对胰腺β细胞功能障碍和糖脂毒性介导的氧化应激的保护作用也得到了严格的审查。最佳参数在很大程度上取决于所应用的提取和分级分离技术以及植物样品的性质。先前的研究已证明迷迭香酸在高血糖症中控制血浆葡萄糖水平和增加胰岛素敏感性的有效作用。尽管迷迭香酸容易被人体吸收，但食用后其机理尚不清楚。应精心计划深入研究以确定迷迭香酸的剂量和毒性水平，以确保疗效和安全食用。先前的研究已证明迷迭香酸在高血糖症中控制血浆葡萄糖水平和增加胰岛素敏感性的有效作用。尽管迷迭香酸容易被人体吸收，但食用后其机理尚不清楚。应该精心计划深入的研究以确定迷迭香酸的剂量和毒性水平，以确保疗效和安全食用。先前的研究已证明迷迭香酸在高血糖症中控制血浆葡萄糖水平和增加胰岛素敏感性的有效作用。尽管迷迭香酸容易被人体吸收，但食用后其机理尚不清楚。应精心计划深入研究以确定迷迭香酸的剂量和毒性水平，以确保疗效和安全食用。