RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programs. They affect diverse eukaryotic biological processes, and the correct deposition of many of these modifications is required for normal development. Messenger RNA (mRNA) modifications regulate various aspects of mRNA metabolism. For example, N6-methyladenosine (m6A) affects the translation and stability of the modified transcripts, thus providing a mechanism to coordinate the regulation of groups of transcripts during cell state maintenance and transition. Similarly, some modifications in transfer RNAs are essential for RNA structure and function. Others are deposited in response to external cues and adapt global protein synthesis and gene-specific translational accordingly and thereby facilitate proper development.

中文翻译：

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RNA 修饰调节发育过程中的基因表达


RNA 修饰最近已成为基因表达程序的关键转录后调节因子。它们影响多种真核生物过程，并且许多这些修饰的正确沉积是正常发育所必需的。信使 RNA (mRNA) 修饰调节 mRNA 代谢的各个方面。例如，N6-甲基腺苷（m6A）影响修饰转录本的翻译和稳定性，从而提供一种在细胞状态维持和转变过程中协调转录本组调节的机制。同样，转移 RNA 中的一些修饰对于 RNA 结构和功能至关重要。其他的则根据外部提示而沉积，并相应地调整整体蛋白质合成和基因特异性翻译，从而促进适当的发育。