Dyes and Pigments ( IF 4.1 ) Pub Date : 2018-09-27 , DOI: 10.1016/j.dyepig.2018.09.067 Krystyna Rozga-Wijas , Malgorzata Sierant , Ewelina Wielgus , Beata J. Miksa
New fluorescent nanocarriers based on the POSS (polyhedral octasilsesquioxanes) nanocage labelled with the photosensitive cationic phenosafranin dye (PSF) provide a useful means for in vitro imaging. In this study, a simply reaction for preparing biocompatible POSS-PSF nanohybrids was successfully developed using a coupling (N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride) agent in a one-step reaction between the amino group of dye molecules and anhydride residues of POSS. The first time are reported fluorescent nanodots as a unique POSS-PSF nanostructure easily transferable by cellular pores due to their cationic charges, which are new intercalative DNA agents useful in anticancer therapies and cellular imaging.
中文翻译:
用光敏阳离子酚红素染料标记的多面体八聚倍半硅氧烷作为用于治疗和细胞成像的新型纳米载体
基于用光敏阳离子苯那弗兰宁染料(PSF)标记的POSS(多面体八聚倍半硅氧烷)纳米笼的新型荧光纳米载体为体外成像提供了有用的手段。在这项研究中,仅仅一用于制备生物相容的POSS-PSF纳米复合物反应,使用联接器(研制成功ñ - - (3-二甲氨基丙基)ñ剂中的氨基的染料分子之间的一步反应'-ethylcarbodiimide盐酸盐) POSS的酸酐残基。首次报道的荧光纳米点是一种独特的POSS-PSF纳米结构,由于其阳离子电荷而易于被细胞孔转移,这是可用于抗癌治疗和细胞成像的新型嵌入DNA试剂。