The n-Propyl Propionate (ProPro) is a compound that has several possible industrial applications. However, the current production route of this component presents several problems, such as the downstream purification. In this way, chromatographic separation could be an alternative solution to the downstream purification. In this work experimental studies of the ProPro reaction system separation in a chromatographic fixed bed unit packed with Amberlyst 46 were performed. The adsorption equilibrium isotherms and the corresponding Langmuir model parameters were determined. A phenomenological model to represent the process was developed and validated through the experimental data. Meanwhile, it is proposed the characterization of the uncertainties of all steps and its extension to the model prediction, which allowed to estimate the model parameters with a reduced number of experiments, when compared with other reports in the literature; nevertheless, the final results lead to a statistically more reliable model.

丙酸正丙酯（ProPro）是一种具有多种可能的工业应用的化合物。但是，该组分的当前生产路线存在一些问题，例如下游纯化。这样，色谱分离可以作为下游纯化的替代解决方案。在这项工作中，在装有Amberlyst 46的色谱固定床装置中进行ProPro反应系统分离的实验研究。确定了吸附平衡等温线并确定了相应的Langmuir模型参数。建立了表示该过程的现象学模型，并通过实验数据对其进行了验证。同时，提出了各步骤不确定性的表征及其对模型预测的扩展，与文献中的其他报告相比，可以减少实验次数来估计模型参数；但是，最终结果导致了统计上更可靠的模型。