Substance use disorders are a widely recognized problem, which affects various levels of communities and influenced the world socioeconomically. Its source is deeply embedded in the global population. In order to fight against such an adversary, governments have spared no efforts in implementing substance abuse treatment centers and funding research to develop treatments and prevention procedures. In this review, we will discuss the use of immunological-based treatments and detection kit technologies. We will be detailing the steps followed to produce performant antibodies (antigens, carriers, and adjuvants) focusing on cocaine and methamphetamine as examples. Furthermore, part of this review is dedicated to substance use detection. Owing to novel technologies such as bio-functional polymeric surfaces and biosensors manufacturing, detection has become a more convenient method with the fast and on-site developed devices. Commercially available devices are able to test substance use disorders in urine, saliva, hair, and sweat. This improvement has had a tremendous impact on the prevention of driving under influence and other illicit behaviors. Lastly, substance abuse became a major issue involving the cooperation of experts on all levels to devise better treatment programs and prevent abuse-based accidents, injury and death.

中文翻译：

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检测、治疗和预防物质使用障碍的新技术

物质使用障碍是一个广为人知的问题，它影响社区的各个层面，并在社会经济上影响着世界。它的来源深深植根于全球人口中。为了对抗这样的对手，各国政府不遗余力地建立药物滥用治疗中心并资助研究以开发治疗和预防程序。在这篇综述中，我们将讨论基于免疫学的治疗和检测试剂盒技术的使用。我们将详细介绍生产高性能抗体（抗原、载体和佐剂）所遵循的步骤，重点是可卡因和甲基苯丙胺作为示例。此外，本综述的一部分专门用于物质使用检测。由于生物功能聚合物表面和生物传感器制造等新技术，随着快速和现场开发的设备，检测已成为一种更方便的方法。市售设备能够测试尿液、唾液、头发和汗液中的物质使用障碍。这一改进对防止酒后驾驶和其他违法行为产生了巨大影响。最后，药物滥用成为一个重大问题，需要各级专家合作制定更好的治疗方案，防止滥用事故、伤害和死亡。