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Seasonality study of essential oil from leaves of Cymbopogon densiflorus and nanoemulsion development with antioxidant activity
Flavour and Fragrance Journal ( IF 2.1 ) Pub Date : 2018-09-26 , DOI: 10.1002/ffj.3472 Janaína Brandão Seibert 1 , Ivanildes Vasconcelos Rodrigues 2 , Simone Pinto Carneiro 1 , Tatiane Roquete Amparo 1 , Juliane Sousa Lanza 3 , Frédéric Jean G. Frézard 3 , Gustavo Henrique Bianco de Souza 1 , Orlando David Henrique dos Santos 1
Flavour and Fragrance Journal ( IF 2.1 ) Pub Date : 2018-09-26 , DOI: 10.1002/ffj.3472 Janaína Brandão Seibert 1 , Ivanildes Vasconcelos Rodrigues 2 , Simone Pinto Carneiro 1 , Tatiane Roquete Amparo 1 , Juliane Sousa Lanza 3 , Frédéric Jean G. Frézard 3 , Gustavo Henrique Bianco de Souza 1 , Orlando David Henrique dos Santos 1
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The development of formulations that maintain the biological and physical chemistry properties of essential oils is an important choice when they are used as an active ingredient. This study aimed to characterize the essential oil from leaves of Cymbopogon densiflorus and evaluate the antioxidant activity of the oil, and to produce a nanoemulsion formulation containing it. The essential oil was obtained by hydrodistillation, and seasonality was analysed every 2 months by gas chromatography–mass spectrometry, showing that more than 90% of the composition was maintained for the whole period and that the major compounds were trans‐p‐menta‐2,8‐dien‐1‐ol, cis‐p‐menta‐2,8‐dien‐1‐ol, trans‐p‐menta‐1(7),8‐dien‐2‐ol, cis‐piperitol, and cis‐p‐menta‐1(7),8‐dien‐2‐ol. Stable nanoemulsions were prepared by phase inversion method encapsulating the essential oil. The antioxidant activity was evaluated by 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) free radical scavenging and 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulphonic acid (ABTS) methods. In the first test, free and nanoemulsified essential oil showed half‐maximal inhibitory concentration (IC50) values equivalent to 14.689 and 3.692 mg mL−1, respectively. In the second test, these values were 0.567 and 0.43 mg mL−1. The development of nanoemulsion‐based essential oil from leaves of C. densiflorus was viable, and the formulated oil was able to reproduce the antioxidant activity at a concentration four times lower than that of the pure essential oil.
中文翻译：
香柏叶精油的季节性研究及具有抗氧化活性的纳米乳剂的研制
当将其用作活性成分时，开发能够保持精油的生物学和物理化学特性的制剂是一个重要的选择。这项研究旨在表征香茅中叶的香精油并评估其抗氧化活性，并生产出一种含有该香精油的纳米乳剂。通过水蒸气蒸馏得到的精油，和季节性是每2个月通过气相色谱-质谱法进行分析，显示出该组合物的90％以上保持在整个时期和主要化合物是反式对-menta -2- ，8-dien-1-ol，顺式-p- menta-2,8-dien-1-ol，反式-p -menta-1（7），8-dien-2-ol，顺式哌啶醇和顺式薄荷脑-1（7），8-二烯-2-醇。通过相转化法包封香精油制备了稳定的纳米乳液。抗氧化剂活性通过2,2-二苯基-1-吡啶甲基肼基（DPPH）清除自由基和2,2'-叠氮基双（3-乙基苯并噻唑啉-6-磺酸）（ABTS）方法进行评估。纳米乳油和半乳化精油的半数抑制浓度（IC 50）分别相当于14.689和3.692 mg mL -1，在第二次测试中分别为0.567和0.43 mg mL -1。茶树的叶子中的精油 这种油是可行的，并且所配制的油能够以比纯精油低四倍的浓度再现抗氧化活性。
更新日期：2018-09-26
中文翻译：
香柏叶精油的季节性研究及具有抗氧化活性的纳米乳剂的研制
当将其用作活性成分时，开发能够保持精油的生物学和物理化学特性的制剂是一个重要的选择。这项研究旨在表征香茅中叶的香精油并评估其抗氧化活性，并生产出一种含有该香精油的纳米乳剂。通过水蒸气蒸馏得到的精油，和季节性是每2个月通过气相色谱-质谱法进行分析，显示出该组合物的90％以上保持在整个时期和主要化合物是反式对-menta -2- ，8-dien-1-ol，顺式-p- menta-2,8-dien-1-ol，反式-p -menta-1（7），8-dien-2-ol，顺式哌啶醇和顺式薄荷脑-1（7），8-二烯-2-醇。通过相转化法包封香精油制备了稳定的纳米乳液。抗氧化剂活性通过2,2-二苯基-1-吡啶甲基肼基（DPPH）清除自由基和2,2'-叠氮基双（3-乙基苯并噻唑啉-6-磺酸）（ABTS）方法进行评估。纳米乳油和半乳化精油的半数抑制浓度（IC 50）分别相当于14.689和3.692 mg mL -1，在第二次测试中分别为0.567和0.43 mg mL -1。茶树的叶子中的精油 这种油是可行的，并且所配制的油能够以比纯精油低四倍的浓度再现抗氧化活性。
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