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Brønsted Acid Mediated Direct α-Hydroxylation of Cyclic α-Branched Ketones
Synlett ( IF 1.7 ) Pub Date : 2018-09-26 , DOI: 10.1055/s-0037-1610292 Benjamin List 1 , Grigory Shevchenko , Stefanie Dehn
Synlett ( IF 1.7 ) Pub Date : 2018-09-26 , DOI: 10.1055/s-0037-1610292 Benjamin List 1 , Grigory Shevchenko , Stefanie Dehn
Affiliation
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We report a Bronsted acid mediated direct α-hydroxylation of cyclic α-branched ketones via a tandem aminoxylation/N–O bond-cleavage process. Nitrosobenzene is used as the oxidant and subsequently promotes the liberation of the free alcohol. The desired products could be isolated in moderate to good yields at a maximum tested scale of 10 mmol. Derivatizations of the obtained products are presented.
中文翻译：
布朗斯台德酸介导的环状α-支链酮的直接α-羟基化
我们报告了布朗斯台德酸介导的环状α-支链酮的直接α-羟基化，通过串联氨氧基化/N-O 键裂解过程。亚硝基苯用作氧化剂，随后促进游离醇的释放。在 10 mmol 的最大测试规模下，可以以中等至良好的产率分离出所需的产物。介绍了所得产品的衍生化。
更新日期：2018-09-26
中文翻译：
布朗斯台德酸介导的环状α-支链酮的直接α-羟基化
我们报告了布朗斯台德酸介导的环状α-支链酮的直接α-羟基化，通过串联氨氧基化/N-O 键裂解过程。亚硝基苯用作氧化剂，随后促进游离醇的释放。在 10 mmol 的最大测试规模下，可以以中等至良好的产率分离出所需的产物。介绍了所得产品的衍生化。
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