The objective of this study was to evaluate periprandial plasma concentrations of glucagon-like peptide-2 (GLP-2), glucose, and β-hydroxybutyrate (BHB) in response to a milk meal in preweaning dairy calves. Nineteen Holstein heifer calves were fed either a high (10 L/d; n = 9) or low (5 L/d; n = 10) amount of pasteurized whole milk from d 2 to 50 of life. Calves were housed in individual pens for the first 19 ± 3 d and fed only milk before being moved to a group pen, where they remained on their respective milk treatment and offered calf starter ad libitum. Blood samples were collected sequentially for 240 min following their milk meal at wk 3, 5, and 7 of life to characterize the periprandial response in plasma concentrations of GLP-2, glucose, and BHB. Baseline plasma glucose concentrations were increased, when a high amount was fed; however, we found no difference in area under the curve. Feeding a high amount of whole milk had no effect on baseline or periprandial plasma BHB concentrations. Baseline plasma GLP-2 concentrations decreased as calves aged. Feeding a high amount of whole milk tended to significantly increase baseline GLP-2 concentrations throughout compared with calves fed a low amount. The periprandial response of GLP-2 was not biphasic until calves were 7 wk old. In conclusion, feeding a high amount of milk may increase GLP-2 concentrations in preweaning calves, although its exact mechanism is unknown.

这项研究的目的是评估断奶前犊牛的乳粉对胰高血糖素样肽2（GLP-2），葡萄糖和β-羟基丁酸酯（BHB）的餐前血浆浓度。从生命的d 2到50，对19头Holstein小母牛犊喂高量（10 L / d； n = 9）或低量（5 L / d； n = 10）的巴氏消毒全脂奶。在开始的19±3 d内，将小牛放在单独的围栏中，在移入组合围栏之前只喂牛奶，在那里他们继续进行各自的牛奶处理，并随意提供犊牛开胃剂。在其生命的第3、5和7周的牛奶餐后，顺序采集血样240分钟，以表征血浆中GLP-2，葡萄糖和BHB浓度对餐前反应的特征。喂高剂量时，基线血浆葡萄糖浓度增加。然而，我们发现曲线下的面积没有差异。喂养大量的全脂牛奶对基线或餐前血浆BHB浓度没有影响。基线血浆GLP-2浓度随犊牛的年龄而降低。与少量饲喂的犊牛相比，饲喂大量全脂牛奶往往会显着增加整个基线的GLP-2浓度。直到小牛7周龄，GLP-2的围产期反应才是两相的。结论是，喂养大量的牛奶可能会增加断奶前犊牛的GLP-2浓度，尽管其确切机制尚不清楚。与少量饲喂的犊牛相比，饲喂大量全脂牛奶往往会显着增加整个基线的GLP-2浓度。直到小牛7周龄，GLP-2的围产期反应才是两相的。结论是，喂养大量的牛奶可能会增加断奶前犊牛的GLP-2浓度，尽管其确切机制尚不清楚。与少量饲喂的犊牛相比，饲喂大量全脂牛奶往往会显着增加整个基线的GLP-2浓度。直到小牛7周龄，GLP-2的围产期反应才是两相的。结论是，喂养大量的牛奶可能会增加断奶前犊牛的GLP-2浓度，尽管其确切机制尚不清楚。