Norcrocrassinone (1), a novel tetranorditerpenoid possessing a fused 6/6/5 ring system, was isolated from the roots of Croton crassifolius. The structure of 1 was elucidated by extensive spectroscopic methods and confirmed by single crystal X-ray diffraction. The anti-Alzheimer’s disease (AD) activity of 1 was evaluated using humanized Caenorhabditis elegans AD pathological model.

中文翻译：

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Norcrocrassinone：一种新的四降二萜类化合物，来自巴豆crassifolius，具有6/6/5稠合环系统

从Croton crassifolius的根中分离出Norcrocrassinone（1），一种具有融合的6/6/5环系统的新型四降二萜类化合物。1的结构通过广泛的光谱学方法阐明，并通过单晶X射线衍射确认。使用人源化秀丽隐杆线虫AD病理模型评估了1的抗阿尔茨海默氏病（AD）活性。