By feeding L-tyrosine into the culture medium, nine undescribed compounds, termed as armochaetoglasins A-I, together with three known analogues, namely armochaetoglobin E, chaetoglobosin V, and chaetoglobosin J, were isolated and identified from the medicinal terrestrial arthropod-derived fungus Chaetomium globosum TW1-1. Their structures were elucidated by means of NMR spectroscopy, single-crystal X-ray crystallography, and comparison of their electronic circular dichroism (ECD) spectra. Structurally, armochaetoglasin A represented the first tyrosine-derived cytochalasan alkaloid characterized by a 13-membered carbocyclic ring system; armochaetoglasins B and C possessed a rare 19,20-seco-chaetoglobosin skeleton. Armochaetoglasin B, chaetoglobosin V, and chaetoglobosin J showed weak cytotoxic activity with IC50 values ranging from 19.5 to 34.72 μM.

中文翻译：

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Armochaetoglasins A–I：通过饲喂 L-酪氨酸从球毛壳菌 TW1-1 发酵液中提取的细胞松弛素生物碱

通过将 L-酪氨酸加入培养基中，从药用陆生节肢动物来源的真菌 Chaetomium globosum 中分离并鉴定出九种未描述的化合物，称为 armochaetoglasins AI，以及三种已知的类似物，即 armochaetoglobin E、chaetoglobosin V 和 chaetoglobosin J。 TW1-1。通过核磁共振光谱、单晶 X 射线晶体学和电子圆二色性 (ECD) 光谱的比较阐明了它们的结构。在结构上，armochaetoglasin A 代表了第一个酪氨酸衍生的细胞松弛素生物碱，其特征是一个 13 元碳环系统；armochaetoglasins B 和 C 具有罕见的 19,20-seco-chaetoglobosin 骨架。Armochaetoglasin B、chaetoglobosin V 和 chaetoglobosin J 显示出微弱的细胞毒活性，IC50 值范围为 19.5 到 34.72 μM。