The synthesis and full characterization of a family of sustainable luminescent nanoparticles, [email protected], made of quantum dots coated by modified mesoporous silica nanoparticles is reported. The presence of the luminescent QDs allows the imaging of the nanoparticles during cell internalization, as well as the visualization of selective release of doxorubicin inside the cell (via pH stimuli). The modified mesoporous silica nanoparticles lead to pore size improvement allowing better encapsulation and controlled release, of different active principles studied such as, small molecules (rhodamine B), drugs (doxorubicin), and isolated proteins such as bovine serum albumin, lysozyme, carbonic anhydrase, ovalbumin, α-lactalbumin, hemoglobin, myoglobin and cytochrome C. Finally, and as a proof-of-concept the efficacy of these novel platforms was demonstrated through the successful extraction and recognition of proteins in raw serum of osteoarthritis and prosthesis patients, without any previous protein depletion.

报道了由改性介孔二氧化硅纳米粒子包覆的量子点组成的一类可持续发光纳米粒子的合成和完整特性[受电子邮件保护]。发光QD的存在允许在细胞内化过程中对纳米颗粒进行成像，并可视化阿霉素在细胞内的选择性释放（通过pH刺激）。改性的介孔二氧化硅纳米颗粒可改善孔径，从而更好地封装和控制释放，其中所研究的不同活性成分如小分子（若丹明B），药物（阿霉素）和分离的蛋白质如牛血清白蛋白，溶菌酶，碳酸酐酶，卵清蛋白，α-乳清蛋白，血红蛋白，肌红蛋白和细胞色素C。最后，