Encoding function into polypeptide-oligonucleotide precision biopolymers†,Chemical Communications

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Encoding function into polypeptide-oligonucleotide precision biopolymers†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-09-26 00:00:00 , DOI: 10.1039/c8cc04725a
Weina Liu ₁ , Felix Boldt , Yu Tokura , Tao Wang , Bikram Keshari Agrawalla , Yuzhou Wu , Tanja Weil

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We report a novel synthesis strategy to prepare precision polymers providing exact chain lengths, molecular weights and monomer sequences that allow post modifications by convenient DNA hybridization. Two grafted single strand DNA (ssDNA) side chains serve as a versatile platform for sequence-specific attachment of chromophores, proteins, cell-targeting peptide, and a Y-shape DNA linker. This approach resembles a LEGO®-type incorporation of functionalities to create functional biopolymers of high structure definition under mild conditions.

中文翻译：

将功能编码为多肽-寡核苷酸精密生物聚合物†

我们报告了一种新的合成策略，用于制备精密聚合物，提供精确的链长、分子量和单体序列，允许通过方便的 DNA 杂交进行后修饰。两条嫁接的单链 DNA (ssDNA) 侧链可作为生色团、蛋白质、细胞靶向肽和 Y 形 DNA 接头的序列特异性连接的多功能平台。这种方法类似于乐高®类型的功能整合，可在温和条件下创建具有高结构清晰度的功能性生物聚合物。

更新日期：2018-09-26

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