Site-specific one-pot triple click labeling for DNA and RNA†,Chemical Communications

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Site-specific one-pot triple click labeling for DNA and RNA†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-09-26 00:00:00 , DOI: 10.1039/c8cc04520h
Marie-Luise Winz _{1,

2,

3,

4} , Eva Christina Linder _{1,

2,

3,

4} , Juliane Becker _{1,

2,

3,

4} , Andres Jäschke _{1,

2,

3,

4}

Affiliation

We report site-specific triple click labeling for DNA and RNA in a one-pot setup by performing inverse electron demand Diels–Alder reaction and strain-promoted and copper catalyzed click reactions sequentially. Our methodology can be applied to long and short nucleic acids alike, and could have broader potential for labeling other (bio-)molecules.

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