Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection†,Chemical Communications

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Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-09-26 00:00:00 , DOI: 10.1039/c8cc06068a
Tatsuya Nishihara _{1,

2,

3} , Satoshi Kuno _{3,

4,

5} , Hiroshi Nonaka _{3,

4,

5} , Sho Tabata _{1,

2,

3} , Natsumi Saito _{3,

6,

7} , Shinji Fukuda _{1,

2,

3,

8,

9} , Masaru Tomita _{1,

2,

3} , Shinsuke Sando _{3,

4,

5,

5,

10} , Tomoyoshi Soga _{1,

2,

3}

Affiliation

Tumor biomarkers are highly desirable for the screening of patients with a risk of tumor development and progression. Here, we report a beta-galactosidase (β-gal)-responsive acetaminophen (β-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection. Tumor β-gal labeling via the recognition of tumor-related antigen enabled the detection of a tumor using β-GR-APAP.

中文翻译：

β-半乳糖苷酶反应性合成生物标记物可用于靶向肿瘤检测†

肿瘤生物标志物对于筛选具有肿瘤发生和发展风险的患者是非常需要的。在这里，我们报告β-半乳糖苷酶（β-gal）响应的对乙酰氨基酚（β-GR-APAP）作为合成的血浆生物标记物，用于靶向肿瘤检测。通过识别肿瘤相关抗原进行肿瘤β-gal标记，可以使用β-GR-APAP检测肿瘤。

更新日期：2018-09-26

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