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Antifouling Super Water Absorbent Supramolecular Polymer Hydrogel as an Artificial Vitreous Body
Advanced Science ( IF 14.3 ) Pub Date : 2018-09-25 , DOI: 10.1002/advs.201800711 Hongbo Wang 1 , Yuanhao Wu 1 , Chunyan Cui 1 , Jianhai Yang 1 , Wenguang Liu 1
Advanced Science ( IF 14.3 ) Pub Date : 2018-09-25 , DOI: 10.1002/advs.201800711 Hongbo Wang 1 , Yuanhao Wu 1 , Chunyan Cui 1 , Jianhai Yang 1 , Wenguang Liu 1
Affiliation
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Recently, there has been a high expectation that high water absorbent hydrogels can be developed as an artificial vitreous body. However, the drawbacks associated with in vivo instability, biofouling, uncontrollable in situ reaction time, and injection‐induced precrosslinked fragmentation preclude their genuine use as vitreous substitutes. Here, a supramolecular binary copolymer hydrogel termed as PNAGA‐PCBAA by copolymerization of N‐acryloyl glycinamide (NAGA) and carboxybetaine acrylamide (CBAA) is prepared. This PNAGA‐PCBAA hydrogel physically crosslinked by dual amide hydrogen bonds of NAGA exhibits an ultralow solid content (1.6, 98.4 wt% water content), and shear‐thinning behavior, body temperature extrudability/self‐healability, rapid network recoverability, and very close key parameters (modulus, antifouling/antifibrosis, light transmittance, refractive index, ultrastability) to human vitreous body. It is demonstrated that the hydrogel can be readily injected by a 22G needle into the rabbits' eyes where the gelling network is rapidly recovered. After 16 weeks postoperation, the hydrogel acts as a very stable vitreous substitute without affecting the structure of soft tissues in eye, or eliciting adverse effects. This supramolecular binary copolymer hydrogel finds a broad application in ophthalmic fields as not only a self‐recoverable permanent vitreous substitute, but also transient intraocular filling for prevention of inner tissues in postsurgical eyes.
中文翻译：
防污超吸水性超分子聚合物水凝胶作为人工玻璃体
最近，人们对将高吸水性水凝胶开发为人造玻璃体寄予厚望。然而，与体内不稳定性、生物污染、无法控制的原位反应时间以及注射引起的预交联碎片相关的缺点阻碍了它们作为玻璃体替代品的真正用途。在这里，通过N-丙烯酰甘氨酰胺（NAGA）和羧基甜菜碱丙烯酰胺（CBAA）的共聚制备了一种超分子二元共聚物水凝胶，称为PNAGA-PCBAA 。这种通过 NAGA 双酰胺氢键物理交联的 PNAGA-PCBAA 水凝胶具有超低固含量（1.6，98.4 wt% 水含量）、剪切稀化行为、体温挤出性/自修复性、快速网络恢复性和非常接近的性能。人体玻璃体的关键参数（模量、防污/抗纤维化、透光率、折射率、超稳定性）。结果表明，水凝胶可以很容易地通过 22G 针头注射到兔子的眼睛中，凝胶网络迅速恢复。术后 16 周后，水凝胶可作为非常稳定的玻璃体替代物，不会影响眼内软组织的结构，也不会引起不良影响。这种超分子二元共聚物水凝胶在眼科领域有着广泛的应用，不仅可以作为可自我恢复的永久玻璃体替代品，还可以用于暂时性眼内填充，以预防术后眼睛内部组织的损伤。
更新日期：2018-09-25
中文翻译：
防污超吸水性超分子聚合物水凝胶作为人工玻璃体
最近，人们对将高吸水性水凝胶开发为人造玻璃体寄予厚望。然而，与体内不稳定性、生物污染、无法控制的原位反应时间以及注射引起的预交联碎片相关的缺点阻碍了它们作为玻璃体替代品的真正用途。在这里，通过N-丙烯酰甘氨酰胺（NAGA）和羧基甜菜碱丙烯酰胺（CBAA）的共聚制备了一种超分子二元共聚物水凝胶，称为PNAGA-PCBAA 。这种通过 NAGA 双酰胺氢键物理交联的 PNAGA-PCBAA 水凝胶具有超低固含量（1.6，98.4 wt% 水含量）、剪切稀化行为、体温挤出性/自修复性、快速网络恢复性和非常接近的性能。人体玻璃体的关键参数（模量、防污/抗纤维化、透光率、折射率、超稳定性）。结果表明，水凝胶可以很容易地通过 22G 针头注射到兔子的眼睛中，凝胶网络迅速恢复。术后 16 周后，水凝胶可作为非常稳定的玻璃体替代物，不会影响眼内软组织的结构，也不会引起不良影响。这种超分子二元共聚物水凝胶在眼科领域有着广泛的应用，不仅可以作为可自我恢复的永久玻璃体替代品，还可以用于暂时性眼内填充，以预防术后眼睛内部组织的损伤。
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