Nucleophilic 5-endo-trig cyclisation was achieved in 2,2-difluorohomoallylic alcohols. Upon treatment with potassium hydride, 2,2-difluorohomoallylic alcohols underwent an intramolecular S_N2′-type reaction to afford 3-fluoro-2,5-dihydrofurans in high yields. In addition, the oxidation of these dihydrofurans formed 4-fluorofuran-2(5H)-ones. Thus, ring-fluorinated furan derivatives were efficiently obtained via allylic sp³ carbon–fluorine bond cleavage.

中文翻译：

---

通过亲核的5-内-trig环化作用使2,2-二氟同烯丙基醇中的 sp ³碳-氟键活化：3-氟代呋喃衍生物的合成†

在2，2-二氟均烯丙基醇中实现了亲核性5-内-trig环化。在用氢化钾处理，2,2- difluorohomoallylic醇进行分子内小号_Ñ 2'-型反应，得到3-氟-2,5-二氢呋喃高收率。此外，这些二氢呋喃的氧化形成了4-氟呋喃-2（5 H）-one 。因此，通过烯丙基sp ³碳-氟键裂解可有效获得环氟化呋喃衍生物。