Understanding Central Nervous System Effects of Deliriant Hallucinogenic Drugs through Experimental Animal Models.,ACS Chemical Neuroscience

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Understanding Central Nervous System Effects of Deliriant Hallucinogenic Drugs through Experimental Animal Models.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-10-16 , DOI: 10.1021/acschemneuro.8b00433
Andrey D Volgin _{1,

2,

3} , Oleg A Yakovlev _{1,

2,

3} , Konstantin A Demin ₂ , Polina A Alekseeva ₂ , Evan J Kyzar _{4,

5} , Christopher Collins ₅ , David E Nichols ₆ , Allan V Kalueff _{7,

8,

9,

10,

11,

12,

13}

Affiliation

Institute of Translational Biomedicine, St. Petersburg State University , St. Petersburg 199034 , Russia.
Almazov National Medical Research Centre , St. Petersburg 197341 , Russia.
Military Medical Academy , St. Petersburg 194044 , Russia.
College of Medicine , University of Illinois at Chicago , Chicago , Illinois 60612 , United States.
The International Zebrafish Neuroscience Research Consortium (ZNRC) , New Orleans , Louisiana 70458 , United States.
Eshelman School of Pharmacy , University of North Carolina, Chapel Hill , North Carolina 27599 , United States.
School of Pharmacy , Southwest University , Chongqing 400716 , China.
Scientific Research Institute of Physiology and Basic Medicine , Novosibirsk 630117 , Russia i.
Ural Federal University , Ekaterinburg 620075 , Russia.
ZENEREI Research Center , Slidell , Louisiana 70458 , United States.
Laboratory of Biological Psychiatry , Institute of Translational Biomedicine, St. Petersburg State University , St. Petersburg 199034 , Russia.
Institute of Experimental Medicine, Almazov National Medical Research Centre , St. Petersburg 197341 , Russia.
Granov Russian Center of Radiology and Surgical Technologies , St. Petersburg 197758 , Russia.

Hallucinogenic drugs potently alter human behavior and have a millennia-long history of use for medicinal and religious purposes. Interest is rapidly growing in their potential as CNS modulators and therapeutic agents for brain conditions. Antimuscarinic cholinergic drugs, such as atropine and scopolamine, induce characteristic hyperactivity and dream-like hallucinations and form a separate group of hallucinogens known as "deliriants". Although atropine and scopolamine are relatively well-studied drugs in cholinergic physiology, deliriants represent the least-studied class of hallucinogens in terms of their behavioral and neurological phenotypes. As such, novel approaches and new model organisms are needed to investigate the CNS effects of these compounds. Here, we comprehensively evaluate the preclinical effects of deliriant hallucinogens in various animal models, their mechanisms of action, and potential interplay with other signaling pathways. We also parallel experimental and clinical findings on deliriant agents and outline future directions of translational research in this field.

中文翻译：

通过实验动物模型了解Deliriant致幻药的中枢神经系统作用。

致幻剂有效地改变了人类的行为，并有千年的历史，用于药物和宗教用途。作为中枢神经系统调节剂和脑病治疗剂的潜力正在迅速增长。抗毒蕈碱胆碱能药物，例如阿托品和东pol碱，会诱发特征性的过度活跃和梦幻般的幻觉，并形成单独的一组致幻剂，称为“ deliriants”。尽管阿托品和东pol碱在胆碱能生理学方面是研究相对透彻的药物，但就行为和神经学表型而言，脱逃剂代表了对致幻剂研究最少的一类。因此，需要新颖的方法和新的模式生物来研究这些化合物的中枢神经系统作用。这里，我们全面评估错觉致幻剂在各种动物模型中的临床前作用，它们的作用机制以及与其他信号通路的潜在相互作用。我们还将平行研究关于脱臭剂的实验和临床发现，并概述该领域转化研究的未来方向。

更新日期：2018-09-25

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