Photoacoustic and Magnetic Resonance Imaging Bimodal Contrast Agent Displaying Amplified Photoacoustic Signal,Small

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Photoacoustic and Magnetic Resonance Imaging Bimodal Contrast Agent Displaying Amplified Photoacoustic Signal
Small ( IF 13.0 ) Pub Date : 2018-09-24 , DOI: 10.1002/smll.201800652
Yukun Duan ₁ , Yu Xu _{2,

3} , Duo Mao ₁ , Weng Heng Liew ₄ , Bing Guo ₁ , Shaowei Wang ₁ , Xiaolei Cai ₁ , Nitish Thakor _{2,

3} , Kui Yao ₄ , Chong-Jing Zhang ₅ , Bin Liu _{1,

2,

4}

Affiliation

Progress in photoacoustic (PA) and magnetic resonance imaging (MRI) bimodal contrast agents has been achieved mainly by utilizing the imaging capability of single or multiple components and consequently realizing the desired application for both imaging modalities. However, the mechanism of the mutual influence between components within a single nanoformulation, which is the key to developing high‐performance multimodal contrast agents, has yet to be fully understood. Herein, by integrating conjugated polymers (CPs) with iron oxide (IO) nanoparticles using an amphiphilic polymer, a bimodal contrast agent named CP‐IO is developed, displaying 45% amplified PA signal intensity as compared to bare CP nanoparticle, while the performance of MRI is not affected. Further experimental and theoretical simulation results reveal that the addition of IO nanoparticles in CP‐IO nanocomposites contributes to this PA signal amplification through a synergistic effect of additional heat generation and faster heat dissipation. Besides, the feasibility of CP‐IO nanocomposites acting as PA‐MRI bimodal contrast agents is validated through in vivo tumor imaging using mice models. From this study, it is demonstrated that a delicately designed structural arrangement of various components in a contrast agent could potentially lead to a superior performance in the imaging capability.

中文翻译：

显示放大的光声信号的光声和磁共振成像双峰造影剂

光声（PA）和磁共振成像（MRI）双峰造影剂的进展主要是通过利用单个或多个组件的成像能力，从而实现了两种成像模态的理想应用。但是，单个纳米制剂中各组分之间相互影响的机制（这是开发高性能多峰造影剂的关键）尚未得到充分理解。本文中，通过使用两亲性聚合物将共轭聚合物（CPs）与氧化铁（IO）纳米颗粒集成在一起，开发了一种名为CP-IO的双峰造影剂，与裸露的CP纳米颗粒相比，其显示了45％的放大PA信号强度，而MRI不受影响。进一步的实验和理论模拟结果表明，在CP‐IO纳米复合材料中添加IO纳米颗粒通过产生更多热量和更快散热的协同作用，有助于PA信号放大。此外，CP-IO纳米复合材料用作PA-MRI双峰造影剂的可行性已通过小鼠模型的体内肿瘤成像得到验证。从这项研究中可以证明，造影剂中各种成分的精心设计的结构布置可能会导致成像性能优异。CP-IO纳米复合材料作为PA-MRI双峰造影剂的可行性已通过小鼠模型的体内肿瘤成像得到验证。从这项研究中可以证明，造影剂中各种成分的精心设计的结构布置可能会导致成像性能优异。CP-IO纳米复合材料作为PA-MRI双峰造影剂的可行性已通过小鼠模型的体内肿瘤成像得到验证。从这项研究中可以证明，造影剂中各种成分的精心设计的结构布置可能会导致成像性能优异。

更新日期：2018-09-24

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