BACKGROUND Chemical, physical and psychological stressors due to the 2010 Deepwater Horizon oil spill may impact coronary heart disease (CHD) among exposed populations. Using longitudinal information from two interviews in the Gulf Long Term Follow-up (GuLF) STUDY, we assessed CHD among oil spill workers and community members. OBJECTIVE To assess the associations between duration of oil spill clean-up work, residential proximity to the oil spill, and incidence of self-reported myocardial infarction or fatal CHD. METHODS Among respondents with two GuLF STUDY interviews (n = 21,256), there were 395 first incident heart disease events (self-reported myocardial infarction or fatal CHD) across 5 years. We estimated hazard ratios (HR) and 95% confidence intervals (95%CI) for associations with duration of oil spill clean-up work and residential proximity to the oil spill. To assess potential impacts of non-response, we compared covariate distributions for those who did (n = 21,256) and did not (n = 10,353) complete the second interview and used inverse probability (IP) of censoring weights to correct for potential non-response bias. RESULTS Living in proximity to the oil spill (vs. living further away) was associated with heart disease, with [HR(95%CI) = 1.30(1.01-1.67)] and without [1.29(1.00-1.65)] censoring weights. For work duration, hazard of heart disease appeared to be higher for those who worked > 180 days (vs. 1-30 days), with and without censoring weights [1.43(0.91-2.25) and 1.36(0.88-2.11), respectively]. Associations persisted throughout the 5-year follow-up. CONCLUSIONS Residential proximity to the spill and duration of clean-up work were associated with a suggested 29-43% higher hazard of heart disease events. Associations were robust to censoring.

中文翻译：

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Deepwater Horizo​​n发生5年后，在漏油事故工人和社区成员中自我报告的心肌梗塞和致命性冠心病。

背景技术由于2010年Deepwater Horizo​​n漏油事件造成的化学，生理和心理压力可能会影响暴露人群的冠心病（CHD）。利用海湾长期追踪研究中两次访谈的纵向信息，我们评估了漏油工人和社区成员中的冠心病。目的评估溢油清理工作的持续时间，居民与溢油的接近程度以及自我报告的心肌梗塞或致命性冠心病的发生率之间的关联。方法在接受两次GuLF Study访谈的受访者（n = 21,256）中，在5年中有395起首次发生的心脏病事件（自我报告的心肌梗塞或致命的CHD）。我们估计了危险比（HR）和95％置信区间（95％CI）与漏油清理工作的持续时间和居民接近漏油事件的关联。为了评估不回答的潜在影响，我们比较了完成（n = 21,256）和没有（n = 10,353）完成第二次访谈的人的协变量分布，并使用了审查权重的逆概率（IP）来校正潜在的不回答者。反应偏见。结果生活在漏油附近（相对于生活在更远的地方）与心脏病相关，[HR（95％CI）= 1.30（1.01-1.67）]，而没有[1.29（1.00-1.65）]检查重量。就工作时间而言，工作≥180天（相对于1-30天）的人，不论是否检查体重，心脏病的危险性似乎都较高[分别为1.43（0.91-2.25）和1.36（0.88-2.11）]。 。在整个5年的随访期间，协会一直坚持下去。结论住宅附近的溢出物和清理工作的持续时间与心脏病事件的危险性增加29-43％有关。协会对审查制度非常有力。