Antibody Fragment and Affibody ImmunoPET Imaging Agents: Radiolabelling Strategies and Applications.,ChemMedChem

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Antibody Fragment and Affibody ImmunoPET Imaging Agents: Radiolabelling Strategies and Applications.
ChemMedChem ( IF 3.6 ) Pub Date : 2018-11-15 , DOI: 10.1002/cmdc.201800624
Ruisi Fu _{1,

2} , Laurence Carroll ₂ , Gokhan Yahioglu _{1,

3} , Eric O Aboagye ₂ , Philip W Miller ₁

Affiliation

Antibodies have long been recognised as potent vectors for carrying diagnostic medical radionuclides, contrast agents and optical probes to diseased tissue for imaging. The area of ImmunoPET combines the use of positron emission tomography (PET) imaging with antibodies to improve the diagnosis, staging and monitoring of diseases. Recent developments in antibody engineering and PET radiochemistry have led to a new wave of experimental ImmunoPET imaging agents that are based on a range of antibody fragments and affibodies. In contrast to full antibodies, engineered affibody proteins and antibody fragments such as minibodies, diabodies, single-chain variable region fragments (scFvs), and nanobodies are much smaller but retain the essential specificities and affinities of full antibodies in addition to more desirable pharmacokinetics for imaging. Herein, recent key developments in the PET radiolabelling strategies of antibody fragments and related affibody molecules are highlighted, along with the main PET imaging applications of overexpressed antigen-associated tumours and immune cells.

中文翻译：

抗体片段和 Affibody 免疫 PET 成像剂：放射性标记策略和应用。

长期以来，抗体一直被认为是携带诊断医学放射性核素、造影剂和光学探针到患病组织进行成像的有效载体。免疫PET领域将正电子发射断层扫描（PET）成像与抗体相结合，以改善疾病的诊断、分期和监测。抗体工程和 PET 放射化学的最新发展引发了新一波基于一系列抗体片段和亲和体的实验性免疫 PET 成像剂。与完整抗体相比，工程化亲和体蛋白和抗体片段（例如微型抗体、双抗体、单链可变区片段 (scFv) 和纳米抗体）要小得多，但除了更理想的药代动力学外，还保留了完整抗体的基本特异性和亲和力。成像。本文重点介绍了抗体片段和相关亲和体分子的 PET 放射性标记策略的最新关键进展，以及过表达抗原相关肿瘤和免疫细胞的主要 PET 成像应用。

更新日期：2018-11-15

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