The aim of this study was to evaluate the role of bamboo shoot fiber (BSF) in regulating insulin sensitivity in mice. Two BSFs were obtained from D. hamiltonii and D. latiforus. C57BL/6 mice were fed a low-fat diet or a high-fat diet with 10% fiber as cellulose (HFC), or two BSFs (HFDH or HFDL) for 13 weeks. Compared with the HFC group, HFDH and HFDL groups exhibited considerably less body weight gain, lower levels of fasting glucose and insulin, and lower values of glucose areas under the curve during glucose and insulin tolerance tests. BSF groups also had lower glucoses stimulated insulin concentrations. In addition, more phosphorylation of Akt in insulin target tissues was associated with higher protein expression levels of PGC-1α and phosphorylated AMPK and p38 in BSF fed mice. These results indicated that BSF improved insulin sensitivity in high-fat diet-fed mice through enhancing insulin signaling and activating PGC-1α.

这项研究的目的是评估笋纤维（BSF）在调节小鼠胰岛素敏感性中的作用。从汉密尔顿梭菌和拉迪福氏梭菌中获得了两种BSF 。。用低脂饮食或高脂饮食给C57BL / 6小鼠喂食10％纤维素纤维（HFC）或两种BSF（HFDH或HFDL），持续13周。与HFC组相比，HFDH和HFDL组在葡萄糖和胰岛素耐受性测试期间表现出显着更少的体重增加，空腹葡萄糖和胰岛素水平更低，曲线下的葡萄糖面积值更低。BSF组还具有较低的葡萄糖刺激的胰岛素浓度。另外，在用BSF喂养的小鼠中，胰岛素靶组织中Akt的更多磷酸化与PGC-1α和磷酸化的AMPK和p38的较高蛋白表达水平相关。这些结果表明，BSF通过增强胰岛素信号传导和激活PGC-1α来改善高脂饮食喂养小鼠的胰岛素敏感性。