The aim of the study was to assess the effects of dietary supplementation of a Bacillus subtilis based probiotic on broiler bone health. After 43 days, probiotic fed broilers had greater bone mineralization, wall thickness, size, and weight of tibias and femurs compared to the controls. We further found that probiotic fed broilers also had higher serum calcium levels at day 14 and a trend of lower serum c-terminal telopeptide of type I collagen levels, a bone resorption indicator, at day 43. Moreover, the level of serotonin was increased in the raphe nuclei, whereas the concentrations of norepinephrine and dopamine were decreased in the hypothalamus of broilers fed probiotic at day 43. These results indicate that dietary supplementation of a Bacillus subtilis based probiotic improves broiler bone traits, most likely through increased calcium intestinal absorption and reduced bone resorption by inhibiting sympathetic activity via the central serotonergic system.

该研究的目的是评估膳食补充枯草芽孢杆菌益生菌对肉仔鸡骨骼健康的影响。43天后，与对照组相比，用益生菌喂养的肉鸡具有更大的骨矿化度，壁厚，壁厚和胫骨和股骨的重量。我们还发现，用益生菌喂养的肉鸡在第14天时血清钙水平也较高，并且在第43天时血清I型胶原的c末端端肽水平降低，这是骨吸收指标。在第43天，饲喂益生菌的肉鸡的下丘脑中去甲肾上腺素和多巴胺的浓度降低了。这些结果表明，饮食中补充了枯草芽孢杆菌 益生菌可改善肉鸡的骨骼特性，最有可能通过增加钙肠道吸收和通过中枢血清素能系统抑制交感神经活动来降低骨吸收。