Brown adipose tissue (BAT) dissipates fatty acids as heat to maintain body temperature in cold environments. The existence of BAT and beige cells in human adults supplies a promising weight-reduction therapy. The central thermogenic regulation descends through an excitatory neural pathway from the hypothalamus, medullar and spine towards BAT. This sympathoexcitatory thermogenic circuit is controlled by GABAergic (γ-aminobutyric acid) signaling from the thermoregulatory center in the preoptic area and the satiety center in the ventromedial nucleus of the hypothalamus. This review summarizes recent research progresses in thermogenic regulators targeting thermosensory and satiety signals in the central nervous system, and speculates on their potential as antiobesity agents.

棕色脂肪组织（BAT）会以热量形式散发脂肪酸，以在寒冷的环境中维持体温。成年人中BAT和米色细胞的存在提供了一种有希望的减肥疗法。中央产热调节通过兴奋性神经通路从下丘脑，延髓和脊柱向BAT下降。该交感兴奋性产热回路由视光前区的温度调节中心和下丘脑腹膜外腹的饱腹感中心的GABA能（γ-氨基丁酸）信号控制。这篇综述总结了针对中枢神经系统中的热感和饱腹感信号的生热调节剂的最新研究进展，并推测了其作为抗肥胖药的潜力。