Fusarium is a fungal genus spread worldwide commonly associated to the production of several mycotoxins, where fumonisins (FBs) are of major importance due to its prevalence. Since mycotoxins have been reported to cause deleterious effects on mammalians, including carcinogenic, neurotoxic, estrogenic, and immune-suppressive, many countries had established regulations on the tolerated concentrations of such substances in foods and animal feed. Even though many mycotoxins — especially fusariotoxins — are concomitantly found in a single matrix, there is no regulation on co-occurrence levels. This is possibly a result of the lack of data in the literature on the toxicological interactions between different mycotoxins. Considering this, it is of utmost importance to gather what is currently known about the combination of FBs, considered to be the most ubiquitous mycotoxins, with other frequently reported fusariotoxins, such as zearalenone (ZEA), deoxynivalenol (DON), nivalenol (NIV), T-2 toxin (T-2), and other emerging mycotoxins. This paper gives an overview about the toxic effects of fusariotoxins individually and combined to FB₁, also gathering the mechanisms and probable interactions between them. This important information may help to develop regulations covering multi-mycotoxins contamination, a growing concern of current days.

镰刀菌真菌属是一种真菌属，在世界范围内传播，通常与几种霉菌毒素的产生有关，由于其流行性，伏马菌素（FBs）在其中尤为重要。由于据报霉菌毒素对哺乳动物造成有害影响，包括致癌，神经毒性，雌激素和免疫抑制作用，因此许多国家制定了有关食品和动物饲料中此类物质的容许浓度的法规。即使在同一基质中同时发现了许多霉菌毒素，尤其是镰刀菌毒素，但对共存水平却没有任何规定。这可能是由于文献中缺乏有关不同真菌毒素之间毒理学相互作用的数据的结果。考虑到这一点，最重要的是收集有关FB组合的当前已知信息，被认为是最普遍存在的霉菌毒素，还有其他经常报道的融合毒素，如玉米赤霉烯酮（ZEA），脱氧雪茄烯醇（DON），雪茄烯醇（NIV），T-2毒素（T-2）和其他新兴的霉菌毒素。本文概述了镰刀菌毒素单独和联合对FB的毒性作用₁，还收集了它们之间的机制和可能的相互作用。这些重要信息可能有助于制定涵盖多霉菌毒素污染的法规，这是当今人们日益关注的问题。