Design of a Multicompartment Hydrogel that Facilitates Time‐Resolved Delivery of Combination Therapy and Synergized Killing of Glioblastoma,Angewandte Chemie International Edition

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Design of a Multicompartment Hydrogel that Facilitates Time‐Resolved Delivery of Combination Therapy and Synergized Killing of Glioblastoma
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-10-18 , DOI: 10.1002/anie.201806483
Poulami Majumder ₁ , Ulrich Baxa ₂ , Scott T R Walsh ₁ , Joel P Schneider ₁

Affiliation

There is significant current interest in identifying new combination therapies that synergize to treat disease, and it is becoming increasingly clear that the temporal resolution of their administration greatly impacts efficacy. To facilitate effective delivery, a multicompartment hydrogel material was developed that is composed of spherical vesicles interlaced within a self‐assembled peptide‐based network of physically crosslinked fibrils that allows time‐resolved independent co‐delivery of small molecules. This material architecture effectively delivers the EGFR kinase inhibitor Erlotinib (ERL) and Doxorubicin (DOX, DNA intercalator) in an ERL→DOX sequential manner to synergistically kill glioblastoma, the most aggressive form of brain cancer.

中文翻译：

设计一种多室水凝胶，促进联合治疗的时间分辨传递和胶质母细胞瘤的协同杀伤

目前人们对寻找协同治疗疾病的新联合疗法非常感兴趣，并且越来越清楚的是，其给药的时间分辨率极大地影响疗效。为了促进有效递送，开发了一种多室水凝胶材料，该材料由交错在物理交联原纤维的自组装肽网络内的球形囊泡组成，允许小分子的时间分辨独立共同递送。这种材料架构以 ERL→DOX 顺序方式有效地传递 EGFR 激酶抑制剂厄洛替尼 (ERL) 和阿霉素（DOX，DNA 嵌入剂），以协同杀死最具侵袭性的脑癌——胶质母细胞瘤。

更新日期：2018-10-18

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