Leveraging plant exine capsules as pH-responsive delivery vehicles for hydrophobic nutraceutical encapsulation,Food & Function

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Leveraging plant exine capsules as pH-responsive delivery vehicles for hydrophobic nutraceutical encapsulation
Food & Function ( IF 5.1 ) Pub Date : 2018-09-21 00:00:00 , DOI: 10.1039/c8fo01665h
Di Wu _{1,

2,

3,

4,

5} , Youyan Liang _{1,

2,

3,

4} , Kai Huang _{1,

2,

3,

4} , Xinyi Jing _{1,

2,

3,

4} , Bin Li _{1,

2,

3,

4,

5} , Hongshan Liang _{1,

2,

3,

4,

5}

Affiliation

Plant exine capsules are natural microscale capsules that are highly physically robust and chemically resilient. They are extracted from pollen grains and plant spores, and can be used as renewable and safe microcapsules for encapsulation applications. Herein, we report the successful evacuation of natural sunflower pollen grains (SPGs) and Lycopodiastrum casuarinoides spore exine capsules (SECs) and investigated the effects of different loading methods on the encapsulation and release of nobiletin, a model hydrophobic nutraceutical. The compositional and morphological characterizations of SPGs and SECs obtained by the developed extraction protocol confirmed that the inside contents had been removed and hollow pollen cavities were obtained successfully. In addition, coumarin-6, a hydrophobic fluorescent probe, was encapsulated into SPGs and SECs, which proved the possibility of using them to encapsulate hydrophobic nutraceuticals. Furthermore, controlled release in simulated digestive fluids (SDF) was achieved by coating calcium alginate onto the outside of the SPGs and SECs. Looking forward, this may provide an effective and potential delivery model to protect loads from degradation in the stomach and achieve pH-responsive delivery of hydrophobic nutraceuticals after oral administration.

中文翻译：

利用植物exine胶囊作为pH响应性递送载体，用于疏水性营养保健胶囊封装

植物exine胶囊是天然的微型胶囊，具有很高的物理强度和化学弹性。它们是从花粉粒和植物孢子中提取的，可用作封装应用中的可再生和安全的微胶囊。在此，我们报告成功疏散了天然向日葵花粉粒（SPG）和番茄红花casuarinoides孢子囊（SECs），并研究了不同负载方法对诺比列汀（一种疏水性保健食品模型）的包囊和释放的影响。通过开发的提取方案获得的SPG和SEC的组成和形态特征证实，内部内容物已被去除，并且成功获得了空心花粉腔。此外，香豆素6（疏水性荧光探针）被封装在SPG和SEC中，这证明了使用它们来封装疏水性保健食品的可能性。此外，通过将海藻酸钙包衣在SPG和SEC的外部，可以在模拟消化液（SDF）中实现受控释放。期待，

更新日期：2018-09-21

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