Development of Electrochemical Sensor Based on Glassy Carbon Electrode Modified with a Molecularly Imprinted Copolymer and its Application for Detection of Repaglinide,Electroanalysis

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Development of Electrochemical Sensor Based on Glassy Carbon Electrode Modified with a Molecularly Imprinted Copolymer and its Application for Detection of Repaglinide
Electroanalysis ( IF 2.7 ) Pub Date : 2018-09-21 , DOI: 10.1002/elan.201800322
Mahmoud Roushani ₁ , Zeynab Jalilian ₂

Affiliation

At the present study, we have reported a new sensor based on immobilized molecularly imprinted polymer on the surface of a glassy carbon electrode (GCE) through electro polymerization of o‐Dihydroxybenzene (o‐DB) and o‐phenylenediamine (o‐PD) as monomers for direct determination of repaglinide (RPG) as target molecule. RPG is a new generation of oral anti‐diabetic drugs that has a rapid onset of action and short half‐life of approximately 1 h. So developing a controlled system with good sensitivity and selectivity is required to eliminate its adverse effects. Under the optimized conditions, the proposed sensor showed a good selectivity to detect RPG among compounds with similar structure and properties with RPG. The linear range for analysis were 0.005–1.0 μM and detection limit 1.8 nM was achieved. Furthermore, the experimental results showed that the proposed sensor was highly selective and sensitive to detect RPG in real samples such as blood serum, urine and RPG tablet.

中文翻译：

分子印迹共聚物修饰的玻碳电极电化学传感器的开发及其在瑞格列奈检测中的应用

在本研究中，我们报告了一种新的传感器，该传感器基于邻二羟基苯（o-DB）和邻苯二胺（o-PD）的电聚合，在玻璃碳电极（GCE）的表面上固定了分子印迹聚合物，直接确定瑞格列奈（RPG）作为目标分子的单体。RPG是新一代的口服抗糖尿病药物，起效迅速，半衰期短于约1小时。因此，需要开发一种具有良好灵敏度和选择性的受控系统，以消除其不利影响。在优化的条件下，所提出的传感器在与RPG具有相似结构和性质的化合物中表现出良好的选择性，可以检测RPG。分析的线性范围为0.005–1.0μM，检测极限为1.8 nM。此外，

更新日期：2018-09-21

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