Modulating Hypoxia via Nanomaterials Chemistry for Efficient Treatment of Solid Tumors,Accounts of Chemical Research

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Modulating Hypoxia via Nanomaterials Chemistry for Efficient Treatment of Solid Tumors
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2018-09-20 00:00:00 , DOI: 10.1021/acs.accounts.8b00214
Yanyan Liu ₁ , Yaqin Jiang ₁ , Meng Zhang ₂ , Zhongmin Tang ₂ , Mingyuan He ₁ , Wenbo Bu _{1,

2}

Affiliation

The common existence of hypoxia in solid tumors has been heavily researched because it renders tumors more resistant to most standard therapeutic methods, such as radiotherapy (RT), chemotherapy, and photodynamic therapy (PDT), and is associated with a more malignant phenotype and poor survival in patients with tumors. The development of hypoxia modulation methods for advanced therapeutic activity is therefore of great interest but remains a considerable challenge. Since the significant development of nanotechnology and nanomedicine, functionalized nanomaterials can be exploited as adjuvant “drugs” for these oxygen-dependent standard therapies or as hypoxia initiators for advanced new therapies to solid tumors.

中文翻译：

通过纳米材料化学调节缺氧以有效治疗实体瘤

实体瘤中普遍存在的缺氧现象已被大量研究，因为它使肿瘤对大多数标准治疗方法（例如放疗（RT），化学疗法和光动力疗法（PDT））具有更强的抵抗力，并且与更恶性的表型和不良的肿瘤相关肿瘤患者的生存率。因此，发展具有先进治疗活性的缺氧调节方法引起了人们的极大兴趣，但仍然是一个巨大的挑战。由于纳米技术和纳米医学的显着发展，功能化的纳米材料可以用作这些氧依赖性标准疗法的佐剂“药物”，也可以作为缺氧引发剂用于实体瘤的先进新疗法。

更新日期：2018-09-20

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