Cinchona-alkaloid-catalyzed hydroxymethylation of 3-fluorooxindoles using paraformaldehyde as the C1 unit was achieved. A wide range of 3-fluorooxindoles was successfully reacted to give the corresponding 3-fluoro-3-hydroxymethyloxindoles with high efficiency and moderate to good enantioselectivity.

中文翻译：

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金鸡纳生物碱催化的3-氟羟吲哚与多聚甲醛的对映选择性羟甲基化

使用多聚甲醛作为C1单元，实现了金鸡纳生物碱催化的3-氟代吲哚的羟甲基化反应。各种各样的3-氟代羟吲哚成功地反应生成了相应的3-氟-3-羟甲基羟甲基吲哚，具有高效率和中等至良好的对映选择性。